Even starker data for worker deaths
– nurses/midwives 71% BAME
– doctors/dentists* 94%
– healthcare support workers 56%
ah the data set is EXTREMELY small just 106 people
38 of whom were white
64 were born outside UK
* FFS only 1 dentist + 1 dental worker
ONLY 4 of the BAME were born in the UK
The sex ratio is strange
52F 48M
I guess medics are mostly female
London/SE account for 47%
It seems PPE worked; none of the dead medical staff worked in ICU.
New: ITV News National Editor Allegra Stratton is leaving to work for Chancellor Rishi Sunak as Director of Strategic Communications at the Treasury, ITV News staff have been told in an email.
I live in Oldham and this story has been trying to get out for ages but has been continually suppressed by MSM.
It seems that Muslim grooming gangs have been operating in Oldham for decades but the authorities have kept it quiet.
The ringleader of the Rochdale gang was convicted and imprisoned but what was not publicised was that he was employed by Oldham council as a youth worker.
A bloke named Raja Miah has been investigating and putting things on social media and been subject to regular death threats from an out of control muzzie community.
It is alleged that the now labour MP Jim McMahon (who was at the relevant time chief executive of Oldham council) was complicit in a cover up of a story involving mass grooming and rape of underaged local white kids by Muslim gangs in unused commercial premises where they set up unlicensed shisha bars etc.
An email was published where a local bbc reporter was asked by McMahon not to publish the story because it might inflame tensions on the day of Lee Rugby’s funeral. McMahon promised cooperation when the heat of the Lee Rigby situation subsided. The story has never since been aired. It should be a national scandal.
There is so much more evidence of a Muslim
takeover of the oldham Labour Party and the plan to islamify this once proud town that is far too voluminous to summarise here.
Councillors and advisers to McMahon are allegedly mixed up on all kinds of dodgy stuff from buying council land cheap to build mosques to employing convicted drug dealers and loads more besides.
If you google “raja miah, recuscient nine” it will keep you busy for hours and make your blood boil.
Doctors have warned that heeding the US president’s comments on using disinfectants or UV light to treat coronavirus could have fatal consequences.
bbc.in/3cNjX6Z
10pm BBC1 news Saturday night and breaking news according to the Asian girl reading it. Boris is back to work on Monday. How much does the news people cost us licence payers (I know we should stop)? What are those 450 people they are keeping on doing? I am sure either here, the DM or Guido told me yesterday that Boris would be back at work on Monday.
Kuenssberg studied history at the University of Edinburgh, followed by a journalism course at Georgetown University in Washington, D.C.,[where she worked on an NBC News political programme.
Which, apparently, qualifies her to attack the government on all fronts from logistics to science, what an education she must have recieved
Studied ? generally means chucked out and did not qualify, hmm I’ve studied nuclear physics (read a book)
Has anyone esle noticed the complete and utter lack of qualifications of bbc journalists to be qualified about what they talk ? any search will do just google the uneducated bunch
One doesn’t have to be educated
Take he small boy in the tale of the Emperor’s new suit.
However one can be diseducated like the lying courtesans and our lying agenda pushing media in their fantasy world.
These days old grannies and truck drivers ask better questions than the Oxbridge journos.
R4 – Monbiot and friends discuss the future. Lotsa professors with Mary Ann Seekheart (?)
Climate change: Nice things about China, but not the bad USA. The elderly are leaving the youth with a bad heritage. Blah, blah. Apparently the old fogies are not with the ‘Zeitgeist’; very intellectual stuff.
Same old, same old. Waiting for the Quiz is hardly worthwhile…
News says Border Farce have ‘stopped’ three boatloads of ‘migrants’. By taking them to Dover. Where they were tested for Coronavirus. That’s the way to do it if you can’t get a test!
Apparently mosques are being hit by the Chinese virus, as no visitors = no donations.
Boo hoo, I’m heartbroken, but take comfort in the fact they will no doubt be begging for public subsidies, which the supine authorities will be only too wiling to grant.
Meanwhile it is reported that the authorities in various European countries have turned a blind eye to illegal Ramavan gatherings.
Muslims praying on top of a building in downtown Athens, while gatherings are forbidden because of COVID-19 pic.twitter.com/Dqf6mUEAol
Oh, dear. Poor Mr Innocent Sopel is upset that Donald Trump might not do any more briefings following the media’s porkies about disinfectant.
Surely the purpose is to inform the American public. Vast majority of questions were not hostile, but to get information from #coronavirus panel. Would be awful if this was a political calculation in wake of the #disinfectant briefing https://t.co/o7HPZwazYs
For those who may not have seen it, here is a fuller transcript of what was being talked about that led to the now infamous remarks.
It’s quite clear. He was talking about ultra violet light and whether there was some way to inject it into the body. The ‘disinfectant’ is presumably a reference to properties of the the UV light itself.
Sopel knows this, as he refers in an earlier tweet to the existence online of these transcripts where he is using it to (in his own mind) catch the President out. So he must have read it, and is happy to carry on lying.
It really won’t do you any good. I broke the habit of a lifetime and responded to someone who had replied to my comment on Twitter to Mr Sopel. I was trying to get to the root of why he thought the President had suggested injecting disinfectant.
It remained civil and I quote from part of the last response (to date): “there can be no ambiguity that his thought process was that testing on direct injection of disinfectant was possible”.
There’s no arguing or reasoning with a mindset that believes they can read thoughts. Context doesn’t matter when you are a mind reader. I will not be engaging further. There is no point, and even if I had changed his mind it would be one person amongst the millions – no, billions that the media has manipulated.
Roland – I monitor twitter now – more so because I have largely excluded the BBC from my life – I have never ‘twittered ‘ and never will – nor uptick or retweet .
I think a big element of entrenched views just shouting at each other – and there are people called FTBE or similar which seems to be some ‘Remainer ‘ club …..
The funny stuff can be good though – but I’ve stopped looking at the comments because there are a lot of people with no sense of humour .
As for this site – the chinese virus – as I suppose is inevitable – has taken over . But the site is a lot busier which is good and still fairly troll free ….
Taffman – I think the BBC is concerned about the composition of SAGE – are blacks and Pakistanis and queer types adequately represented . Also – why isn’t it broadcasted on live TV in a ‘dancing format ‘ with a compare and studio audience ?
Sometimes it’s a bit desperate isn’t it ….. ?
Tucker on Biden’s #MeToo from 1993
that CNN couldn’t find even though it was on a CNN show.
Tucker Carlson talks about the recently unearthed video that appears to show Tara Reade's (@ReadeAlexandra) mother talking about her allegations against then Senator Joe Biden. pic.twitter.com/eKpSSxgrDu
In a country in which white people make up 96% of the population, why is it that the BBC invariably uses images of BAME people (mostly women) to illustrate Scotland-specific pieces relating to Covid-19?
Answers on a (non-alcoholic) beer mat to the usual address.
As usual, now Sky is following the footsteps of BBC spreading fake news! What’s the source of this info? The authorities are doing a far better job than any other country. I would like to see Sky covering what’s happening to so many homeless in the UK and the crisis NHS is facing
immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Rodrigo Arreola, 1 , * Saray Quintero-Fabián, 2 Rocío Ivette López-Roa, 3 Enrique Octavio Flores-Gutiérrez, 4 Juan Pablo Reyes-Grajeda, 5 Lucrecia Carrera-Quintanar, 6 and Daniel Ortuño-Sahagún 6 , *
Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.
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Abstract
The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences in final composition and compound proportion. In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils, by mechanisms including modulation of cytokine secretion, immunoglobulin production, phagocytosis, and macrophage activation. Finally, because immune dysfunction plays an important role in the development and progress of several diseases, we critically examined immunoregulation by garlic extracts and compounds isolated, which can contribute to the treatment and prevention of pathologies such as obesity, metabolic syndrome, cardiovascular disorders, gastric ulcer, and even cancer. We concluded that A. sativum modulates cytokine secretion and that such modulation may provide a mechanism of action for many of their therapeutic effects.
C_M,
On one of the previous MedCram videos (sorry, cannot cite the edition number), he refers quite extensively to research into hot baths. Viral infection produces fever. That fever is the body’s natural defences at work and it is recommended that a patient lives with the fever, provided it does not become serious, as to reduce it, artificially stifles the body’s ability to naturally combat the virus. I recall that the researchers found that hot (followed by cold) was beneficial. More research is taking place.
“the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system”
maybe lara c and the rest of this partially educated shower of sh@t missed that one, or more likely does not understand, her national certificate in basketweaving probably does not cover what the immune system is
Garlic has been known about for a long time as has echinacea. Another one that comes to mind is feverfew. There is a branch of medicine called pharmacognosy (alt. non-Microsoft, proper English spelling pharmacognacy) and it is as old as the hills, well as old – at least – as Biblical times. Good old aspirin is made from old cricket bats or something similar.
Thanks to a ‘still in date’ highly discounted offer of garlic stuffed olives the Snuffy household became rather interested in same. Not always up for buying the expensive ones that come with feta cheese at Tesco but there are alternatives available. When left to steep in olive oil, they become truly delicious in my view, likewise the bare cloves.
Don’t do what some silly person did when garlic was first mentioned as a boost to the immune system and buy a heap of garlic and eat it in one go. She, iirc, ended up with burns to her esophagus and the top of her stomach. Garlic can be an intestinal irritant.
Warning over, since eating a garlic stuffed olive (or two) a day, maybe with half a clove, I’ve found I have had less colds and less severe colds than previously. To trial thoroughly, I should give up for a couple of years. Unfortunately, I am now hooked, an addict. The olive oil may possibly be more effective, too, than the cod liver oil was at helping my creaking joints.
If you are worried about the smell on breath in times of non-social distancing, don’t. I haven’t lost any friends. And you can buy odour free garlic pills at health food stores and pharmacies. But, BUT ALWAYS, read and follow the instructions, do not exceed the dosage and if you have a pre-existing health condition, check with your GP or a pharmacist first.
As it is the Sabbath, a quote from Scripture: Revelation 22 vs. 1-4.
And he shewed me a pure river of water of life, clear as crystal, proceeding out of the throne of God and of the Lamb. In the midst of the street of it, and on either side of the river, was there the tree of life, which bare twelve manner of fruits, and yielded her fruit every month: and the leaves of the tree were for the healing of the nations. And there shall be no more curse: but the throne of God and of the Lamb shall be in it; and his servants shall serve him: And they shall see his face; and his name shall be in their foreheads.
1. Salman H., Bergman M., Bessler H., Punsky I., Djaldetti M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. International Journal of Immunopharmacology. 1999;21(9):589–597. doi: 10.1016/s0192-0561(99)00038-7. [PubMed] [CrossRef] [Google Scholar]
2. Reinhart K. M., Talati R., White C. M., Coleman C. I. The impact of garlic on lipid parameters: a systematic review and meta-analysis. Nutrition Research Reviews. 2009;22(1):39–48. doi: 10.1017/s0954422409350003. [PubMed] [CrossRef] [Google Scholar]
3. Eilat-Adar S., Sinai T., Yosefy C., Henkin Y. Nutritional recommendations for cardiovascular disease prevention. Nutrients. 2013;5(9):3646–3683. doi: 10.3390/nu5093646. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
4. Khatua T. N., Adela R., Banerjee S. K. Garlic and cardioprotection: insights into the molecular mechanisms. Canadian Journal of Physiology and Pharmacology. 2013;91(6):448–458. doi: 10.1139/cjpp-2012-0315. [PubMed] [CrossRef] [Google Scholar]
5. Fridman S., Sinai T., Zilberg D. Efficacy of garlic based treatments against monogenean parasites infecting the guppy (Poecilia reticulata (Peters)) Veterinary Parasitology. 2014;203(1-2):51–58. doi: 10.1016/j.vetpar.2014.02.002. [PubMed] [CrossRef] [Google Scholar]
6. Amagase H., Petesch B. L., Matsuura H., Kasuga S., Itakura Y. Intake of garlic and its bioactive components. Journal of Nutrition. 2001;131(supplement 3):955s–962s. [PubMed] [Google Scholar]
7. Sivam G. P. Protection against Helicobacter pylori and other bacterial infections by garlic. Journal of Nutrition. 2001;131(3):1106s–1108s. [PubMed] [Google Scholar]
8. Lawson L. D., Gardner C. D. Composition, stability, and bioavailability of garlic products used in a clinical trial. Journal of Agricultural and Food Chemistry. 2005;53(16):6254–6261. doi: 10.1021/jf050536. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
9. Sivam G. P., Lampe J. W., Ulness B., Swanzy S. R., Potter J. D. Helicobacter pylori—in vitro susceptibility to garlic (Allium sativum) extract. Nutrition and Cancer. 1997;27(2):118–121. doi: 10.1080/01635589709514512. [PubMed] [CrossRef] [Google Scholar]
10. Jonkers D., Sluimer J., Stobberingh E. Effect of garlic on vancomycin-resistant enterococci. Antimicrobial Agents and Chemotherapy. 1999;43(12):p. 3045. [PMC free article] [PubMed] [Google Scholar]
11. Gharavi M. J., Nobakht M., Khademvatan S., Fani F., Bakhshayesh M., Roozbehani M. The effect of aqueous garlic extract on interleukin-12 and 10 levels in Leishmania major (MRHO/IR/75/ER) infected macrophages. Iranian Journal of Public Health. 2011;40(4):105–111. [PMC free article] [PubMed] [Google Scholar]
12. Gharavi M., Nobakht M., Khademvatan S., Bandani E., Bakhshayesh M., Roozbehani M. The effect of garlic extract on expression of INFγ and inos genes in macrophages infected with Leishmania major . Iranian Journal of Parasitology. 2011;6(3):74–81. [PMC free article] [PubMed] [Google Scholar]
13. Gorinstein S., Leontowicz M., Leontowicz H., et al. Supplementation of garlic lowers lipids and increases antioxidant capacity in plasma of rats. Nutrition Research. 2006;26(7):362–368. doi: 10.1016/j.nutres.2006.06.008. [CrossRef] [Google Scholar]
14. Sharma A. K., Munajjam A., Vaishnav B., et al. Involvement of adenosine and standardization of aqueous extract of garlic (Allium sativum Linn.) on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury. Journal of Biomedical Research. 2012;26(1):24–36. doi: 10.1016/s1674-8301(12)60004-9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
15. Durak I., Kavutcu M., Aytaç B., et al. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. Journal of Nutritional Biochemistry. 2004;15(6):373–377. doi: 10.1016/j.jnutbio.2004.01.005. [PubMed] [CrossRef] [Google Scholar]
16. Yoshida H., Katsuzaki H., Ohta R., et al. Antimicrobial activity of the thiosulfinates isolated from oil-macerated garlic extract. Bioscience, Biotechnology and Biochemistry. 1999;63(3):591–594. doi: 10.1271/bbb.63.591. [PubMed] [CrossRef] [Google Scholar]
17. Lawson L. D., Wood S. G., Hughes B. G. HPLC analysis of allicin and other thiosulfinates in garlic clove homogenates. Planta Medica. 1991;57(3):263–270. doi: 10.1055/s-2006-960087. [PubMed] [CrossRef] [Google Scholar]
18. O’Gara E. A., Hill D. J., Maslin D. J. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori . Applied and Environmental Microbiology. 2000;66(5):2269–2273. doi: 10.1128/aem.66.5.2269-2273.2000. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
19. Yoshida H., Iwata N., Katsuzaki H., et al. Antimicrobial activity of a compound isolated from an oil-macerated garlic extract. Bioscience, Biotechnology and Biochemistry. 1998;62(5):1014–1017. doi: 10.1271/bbb.62.1014. [PubMed] [CrossRef] [Google Scholar]
20. Aboelhadid S. M., Kamel A. A., Arafa W. M., Shokier K. A. Effect of Allium sativum and Allium cepa oils on different stages of Boophilus annulatus . Parasitology Research. 2013;112(5):1883–1890. doi: 10.1007/s00436-013-3344-0. [PubMed] [CrossRef] [Google Scholar]
21. Liu C. T., Su H. M., Lii C. K., Sheen L.- Y. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica. 2009;75(3):205–210. doi: 10.1055/s-0028-1088396. [PubMed] [CrossRef] [Google Scholar]
22. Shih P.-C., Kuo C.-H., Juang J.-Y., Liu C.-H., Hsu L., Liu C.-T. Effects of garlic oil on the migration of neutrophil-like cell studied by using a chemotactic gradient labchip. Journal of Biomedicine and Biotechnology. 2010;2010:9. doi: 10.1155/2010/319059.319059 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
23. Lee E. N., Choi Y. W., Kim H. K., et al. Chloroform extract of aged black garlic attenuates TNF-α-induced ROS generation, VCAM-1 expression, NF-κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells. Phytotherapy Research. 2011;25(1):92–100. doi: 10.1002/ptr.3230. [PubMed] [CrossRef] [Google Scholar]
24. Park C., Park S., Chung Y. H., et al. Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells. Nutrition Research and Practice. 2014;8(2):132–137. doi: 10.4162/nrp.2014.8.2.132. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
25. Kim S. R., Jung Y. R., An H. J., et al. Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling. PLoS ONE. 2013;8(9) doi: 10.1371/journal.pone.0073877.e73877 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
26. Imai J., Ide N., Nagae S., Moriguchi T., Matsuura H., Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Medica. 1994;60(5):417–420. doi: 10.1055/s-2006-959522. [PubMed] [CrossRef] [Google Scholar]
27. Borek C. Antioxidant health effects of aged garlic extract. Journal of Nutrition. 2001;131(3):1010S–1015S. [PubMed] [Google Scholar]
28. Badr G. M., Al-Mulhim J. A. The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats. Evidence-Based Complementary and Alternative Medicine. 2014;2014:9. doi: 10.1155/2014/759642.759642 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
29. Uda N., Kashimoto N., Sumioka I., Kyo E., Sumi S.-I., Fukushima S. Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. Journal of Nutrition. 2006;136(3, supplement):855s–860s. [PubMed] [Google Scholar]
30. Quintero-Fabián S., Ortuño-Sahagún D., Vázquez-Carrera M., López-Roa R. I. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators of Inflammation. 2013;2013:11. doi: 10.1155/2013/381815.381815 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
31. Makris A., Thornton C. E., Xu B., Hennessy A. Garlic increases IL-10 and inhibits TNFα and IL-6 production in endotoxin-stimulated human placental explants. Placenta. 2005;26(10):828–834. doi: 10.1016/j.placenta.2004.10.019. [PubMed] [CrossRef] [Google Scholar]
32. Keiss H.-P., Dirsch V. M., Hartung T., et al. Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-κB activity. Journal of Nutrition. 2003;133(7):2171–2175. [PubMed] [Google Scholar]
33. Kang N. S., Moon E. Y., Cho C. G., Pyo S. Immunomodulating effect of garlic component, allicin, on murine peritoneal macrophages. Nutrition Research. 2001;21(4):617–626. doi: 10.1016/S0271-5317(01)00269-X. [CrossRef] [Google Scholar]
34. Feng Y., Zhu X., Wang Q., et al. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malaria Journal. 2012;11, article 268 doi: 10.1186/1475-2875-11-268. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
35. Hanieh H., Narabara K., Piao M., Gerile C., Abe A., Kondo Y. Modulatory effects of two levels of dietary Alliums on immune response and certain immunological variables, following immunization, in White Leghorn chickens. Animal Science Journal. 2010;81(6):673–680. doi: 10.1111/j.1740-0929.2010.00798.x. [PubMed] [CrossRef] [Google Scholar]
36. Washiya Y., Nishikawa T., Fujino T. Enhancement of intestinal IgA production by ajoene in mice. Bioscience, Biotechnology and Biochemistry. 2013;77(11):2298–2301. doi: 10.1271/bbb.130408. [PubMed] [CrossRef] [Google Scholar]
37. Kyo E., Uda N., Kasuga S., Itakura Y. Immunomodulatory effects of aged garlic extract. Journal of Nutrition. 2001;131(3):1075s–1079s. [PubMed] [Google Scholar]
38. Zare A., Farzaneh P., Pourpak Z., et al. Purified aged garlic extract modulates allergic airway inflammation in Balb/c mice. Iranian Journal of Allergy, Asthma and Immunology. 2008;7(3):133–141. [PubMed] [Google Scholar]
39. Clement F., Pramod S. N., Venkatesh Y. P. Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. International Immunopharmacology. 2010;10(3):316–324. doi: 10.1016/j.intimp.2009.12.002. [PubMed] [CrossRef] [Google Scholar]
40. Trio P. Z., You S., He X., He J., Sakao K., Hou D.-X. Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food & Function. 2014;5(5):833–844. doi: 10.1039/c3fo60479a. [PubMed] [CrossRef] [Google Scholar]
41. Jones M. G., Hughes J., Tregova A., Milne J., Tomsett A. B., Collin H. A. Biosynthesis of the flavour precursors of onion and garlic. Journal of Experimental Botany. 2004;55(404):1903–1918. doi: 10.1093/jxb/erh138. [PubMed] [CrossRef] [Google Scholar]
42. Augusti K. T., Jose R., Sajitha G. R., Augustine P. A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in Allium products as ideal agents: a review. Indian Journal of Clinical Biochemistry. 2012;27(1):6–20. doi: 10.1007/s12291-011-0146-y. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
43. Ichikawa M., Ryu K., Yoshida J., et al. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. BioFactors. 2002;16(3-4):57–72. doi: 10.1002/biof.5520160302. [PubMed] [CrossRef] [Google Scholar]
44. Ichikawa M., Yoshida J., Ide N., Sasaoka T., Yamaguchi H., Ono K. Tetrahydro-β-carboline derivatives in aged garlic extract show antioxidant properties. Journal of Nutrition. 2006;136(3, supplement):726s–731s. [PubMed] [Google Scholar]
45. Chandrashekar P. M., Prashanth K. V. H., Venkatesh Y. P. Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract. Phytochemistry. 2011;72(2-3):255–264. doi: 10.1016/j.phytochem.2010.11.015. [PubMed] [CrossRef] [Google Scholar]
46. Mahima, Rahal A., Deb R., et al. Immunomodulatory and therapeutic potentials of herbal, traditional/indigenous and ethnoveterinary medicines. Pakistan Journal of Biological Sciences. 2012;15(16):754–774. doi: 10.3923/pjbs.2012.754.774. [PubMed] [CrossRef] [Google Scholar]
47. Spelman K., Burns J. J., Nichols D., Winters N., Ottersberg S., Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative Medicine Review. 2006;11(2):128–150. [PubMed] [Google Scholar]
48. You S., Nakanishi E., Kuwata H., et al. Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators. Molecular Nutrition & Food Research. 2013;57(11):2049–2060. doi: 10.1002/mnfr.201200843. [PubMed] [CrossRef] [Google Scholar]
49. Fu E., Tsai M.-C., Chin Y.-T., et al. The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor-kappa B activation in human gingival fibroblasts. Journal of Periodontal Research. 2014 doi: 10.1111/jre.12217. [PubMed] [CrossRef] [Google Scholar]
50. Ho C. Y., Weng C. J., Jhang J. J., Cheng Y. T., Huang S. M., Yen G. C. Diallyl sulfide as a potential dietary agent to reduce TNFalpha- and histamine-induced proinflammatory responses in A7r5 cells. Molecular Nutrition and Food Research. 2014;58(5):1069–1078. doi: 10.1002/mnfr.201300617. [PubMed] [CrossRef] [Google Scholar]
51. Jafari R. A., Jalali M. R., Ghorbanpoor M., Saraei S. M. R. Effect of dietary garlic on immune response of broiler chicks to live newcastle disease vaccine. Pakistan Journal of Biological Sciences. 2008;11(14):1848–1851. doi: 10.3923/pjbs.2008.1848.1851. [PubMed] [CrossRef] [Google Scholar]
52. Shibasaki M., Sumazaki R., Isoyama S., Takita H. Interaction of lectins with human IgE: IgE-binding property and histamine-releasing activity of twelve plant lectins. International Archives of Allergy and Immunology. 1992;98(1):18–25. doi: 10.1159/000236160. [PubMed] [CrossRef] [Google Scholar]
53. Gupta A., Sandhu R. S. Mitogenic activity of high molecular weight mannose specific agglutinin. Indian Journal of Biochemistry and Biophysics. 1996;33(4):325–327. [PubMed] [Google Scholar]
54. Vogt L., Meyer D., Pullens G., et al. Immunological properties of inulin-type fructans. Critical Reviews in Food Science and Nutrition. 2015;55(3):414–436. doi: 10.1080/10408398.2012.656772. [PubMed] [CrossRef] [Google Scholar]
55. Watzl B., Girrbach S., Roller M. Inulin, oligofructose and immunomodulation. British Journal of Nutrition. 2005;93:S49–S55. doi: 10.1079/BJN20041357. [PubMed] [CrossRef] [Google Scholar]
56. Chen S., Tang Y., Qian Y., et al. Allicin prevents H2O2-induced apoptosis of HUVECs by inhibiting an oxidative stress pathway. BMC Complementary and Alternative Medicine. 2014;14(1, article 321) doi: 10.1186/1472-6882-14-321. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
57. Xu Y.-S., Feng J.-G., Zhang D., et al. S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro. Acta Pharmacologica Sinica. 2014;35(2):267–274. doi: 10.1038/aps.2013.176. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
58. Bauer D., Mazzio E., Soliman K. F., et al. Diallyl disulfide inhibits TNFα-induced CCL2 release by MDA-MB-231 cells. Anticancer Research. 2014;34(6):2763–2770. [PMC free article] [PubMed] [Google Scholar]
59. Park S. Y., Seetharaman R., Ko M. J., et al. Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. International Immunopharmacology. 2014;19(2):253–261. doi: 10.1016/j.intimp.2014.01.017. [PubMed] [CrossRef] [Google Scholar]
60. Hodge G., Hodge S., Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry. 2002;48(4):209–215. doi: 10.1002/cyto.10133. [PubMed] [CrossRef] [Google Scholar]
61. Oft M. IL-10: master switch from tumor-promoting inflammation to antitumor immunity. Cancer Immunology Research. 2014;2(3):194–199. doi: 10.1158/2326-6066.cir-13-0214. [PubMed] [CrossRef] [Google Scholar]
62. Gazzinelli R. T., Oswald I. P., James S. L., Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ- activated macrophages. Journal of Immunology. 1992;148(6):1792–1796. [PubMed] [Google Scholar]
63. Shin I. S., Hong J., Jeon C. M., et al. Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression. Food and Chemical Toxicology. 2013;62:506–513. doi: 10.1016/j.fct.2013.09.012. [PubMed] [CrossRef] [Google Scholar]
64. Yi X., Feng F., Xiang Z., Ge L. The effects of allitridin on the expression of transcription factors T-bet and GATA-3 in mice infected by murine cytomegalovirus. Journal of Medicinal Food. 2005;8(3):332–336. doi: 10.1089/jmf.2005.8.332. [PubMed] [CrossRef] [Google Scholar]
65. Li Y.-N., Huang F., Liu X.-L., et al. Allium sativum-derived allitridin inhibits treg amplification in cytomegalovirus infection. Journal of Medical Virology. 2013;85(3):493–500. doi: 10.1002/jmv.23480. [PubMed] [CrossRef] [Google Scholar]
66. Ebrahimi M., Hassan Z. M., Mostafaie A., Mehrjardi N. Z., Ghazanfari T. Purified protein fraction of garlic extract modulates cellular immune response against breast transplanted tumors in BALB/c mice model. Cell Journal. 2013;15(1):65–74. [PMC free article] [PubMed] [Google Scholar]
67. Sela U., Ganor S., Hecht I., et al. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004;111(4):391–399. doi: 10.1111/j.0019-2805.2004.01841.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
68. Morioka N., Sze L. L., Morton D. L., Irie R. F. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunology Immunotherapy. 1993;37(5):316–322. doi: 10.1007/BF01518454. [PubMed] [CrossRef] [Google Scholar]
69. Nantz M. P., Rowe C. A., Muller C. E., Creasy R. A., Stanilka J. M., Percival S. S. Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clinical Nutrition. 2012;31(3):337–344. doi: 10.1016/j.clnu.2011.11.019. [PubMed] [CrossRef] [Google Scholar]
70. Hassan Z. M., Yaraee R., Zare N., Ghazanfari T., Nejad A. H. S., Nozari B. Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity. International Immunopharmacology. 2003;3(10-11):1483–1489. doi: 10.1016/S1567-5769(03)00161-9. [PubMed] [CrossRef] [Google Scholar]
71. Ishikawa H., Saeki T., Otani T., et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. Journal of Nutrition. 2006;136(3, supplement):816S–820S. [PubMed] [Google Scholar]
72. Kyo E., Uda N., Suzuki A., et al. Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine. 1998;5(4):259–267. doi: 10.1016/S0944-7113(98)80064-0. [PubMed] [CrossRef] [Google Scholar]
73. Banchereau J., Briere F., Caux C., et al. Immunobiology of dendritic cells. Annual Review of Immunology. 2000;18:767–811. doi: 10.1146/annurev.immunol.18.1.767. [PubMed] [CrossRef] [Google Scholar]
74. Ahmadabad H. N., Hassan Z. M., Safari E., Bozorgmehr M., Ghazanfari T., Moazzeni S. M. Evaluation of the immunomodulatory effect of the 14kDa protein isolated from aged garlic extract on dendritic cells. Cellular Immunology. 2011;269(2):90–95. doi: 10.1016/j.cellimm.2011.02.005. [PubMed] [CrossRef] [Google Scholar]
75. Park J. J., Lee J., Kim M. A., Back S. K., Hong S. K., Na H. S. Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1. Neuroscience Letters. 2007;411(2):87–91. doi: 10.1016/j.neulet.2006.10.046. [PubMed] [CrossRef] [Google Scholar]
76. Ghazanfari T., Hassan Z. M., Ebrahimi M. Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. International Immunopharmacology. 2002;2(11):1541–1549. doi: 10.1016/S1567-5769(02)00052-8. [PubMed] [CrossRef] [Google Scholar]
77. Kao S. H., Hsu C. H., Su S. N., Hor W. T., Chang T W. H., Chow L. P. Identification and immunologic characterization of an allergen, alliin lyase, from garlic (Allium sativum) Journal of Allergy and Clinical Immunology. 2004;113(1):161–168. doi: 10.1016/j.jaci.2003.10.040. [PubMed] [CrossRef] [Google Scholar]
78. Cronin E. Dermatitis of the hands in caterers. Contact Dermatitis. 1987;17(5):265–269. doi: 10.1111/j.1600-0536.1987.tb01475.x. [PubMed] [CrossRef] [Google Scholar]
79. Falleroni A. E., Zeiss C. R., Levitz D. Occupational asthma secondary to inhalation of garlic dust. Journal of Allergy and Clinical Immunology. 1981;68(2):156–160. doi: 10.1016/0091-6749(81)90173-1. [PubMed] [CrossRef] [Google Scholar]
80. Seuri M., Taivanen A., Ruoppi P., Tukiainen H. Three cases of occupational asthma and rhinitis caused by garlic. Clinical and Experimental Allergy. 1993;23(12):1011–1014. doi: 10.1111/j.1365-2222.1993.tb00292.x. [PubMed] [CrossRef] [Google Scholar]
81. Lybarger J. A., Gallagher J. S., Pulver D. W., Litwin A., Brooks S., Bernstein I. L. Occupational asthma induced by inhalation and ingestion of garlic. The Journal of Allergy and Clinical Immunology. 1982;69(5):448–454. doi: 10.1016/0091-6749(82)90120-8. [PubMed] [CrossRef] [Google Scholar]
82. Asero R., Mistrello G., Roncarolo D., Antoniotti P. L., Falagiani P. A case of garlic allergy. Journal of Allergy and Clinical Immunology. 1998;101(3):427–428. doi: 10.1016/s0091-6749(98)70261-1. [PubMed] [CrossRef] [Google Scholar]
83. Pérez-Pimiento A. J., Moneo I., Santaolalla M., De Paz S., Fernández-Parra B., Domínguez-Lázaro A. R. Anaphylactic reaction to young garlic. Allergy. 1999;54(6):626–629. doi: 10.1034/j.1398-9995.1999.00806.x. [PubMed] [CrossRef] [Google Scholar]
84. Clement F., Venkatesh Y. P. Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic. International Immunopharmacology. 2010;10(10):1161–1169. doi: 10.1016/j.intimp.2010.06.022. [PubMed] [CrossRef] [Google Scholar]
85. Yin X., Zhang J., Li X., et al. DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. International Journal of Molecular Sciences. 2014;15(7):12422–12441. doi: 10.3390/ijms150712422. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
86. Senthilkumar G. P., Thomas S., Sivaraman K., Sankar P., Bobby Z. Study the effect of s-methyl L-cysteine on lipid metabolism in an experimental model of diet induced obesity. Journal of Clinical and Diagnostic Research. 2013;7(11):2449–2451. doi: 10.7860/jcdr/2013/7304.3571. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
87. Chandrashekar P. M., Venkatesh Y. P. Identification of the protein components displaying immunomodulatory activity in aged garlic extract. Journal of Ethnopharmacology. 2009;124(3):384–390. doi: 10.1016/j.jep.2009.05.030. [PubMed] [CrossRef] [Google Scholar]
88. Şener G., Sehirli Ö., Ipçi Y., et al. Aqueous garlic extract alleviates isehaemia-reperfusion-induced oxidative hepatic injury in rats. Journal of Pharmacy and Pharmacology. 2005;57(1):145–150. doi: 10.1211/0022357055209. [PubMed] [CrossRef] [Google Scholar]
89. Ernsberger P., Johnson J. L., Rosenthal T., Mirelman D., Koletsky R. J. Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome. American Journal of Hypertension. 2007;20(8):866–874. doi: 10.1016/j.amjhyper.2007.02.015. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
90. Mendis S., Puska P., Norrving B. Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization, World Heart Federation and World Stroke Organization; 2011. [Google Scholar]
91. Kuller L. H., Tracy R. P., Shaten J., Meilahn E. N. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. American Journal of Epidemiology. 1996;144(6):537–547. doi: 10.1093/oxfordjournals.aje.a008963. [PubMed] [CrossRef] [Google Scholar]
92. Ridker P. M., Hennekens C. H., Roitman-Johnson B., Stampfer M. J., Allen J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. The Lancet. 1998;351(9096):88–92. doi: 10.1016/s0140-6736(97)09032-6. [PubMed] [CrossRef] [Google Scholar]
93. Ridker P. M., Hennekens C. H., Buring J. E., Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. The New England Journal of Medicine. 2000;342(12):836–843. doi: 10.1056/nejm200003233421202. [PubMed] [CrossRef] [Google Scholar]
94. Vazquez-Prieto M. A., Rodriguez Lanzi C., Lembo C., Galmarini C. R., Miatello R. M. Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. Journal of Nutrition and Metabolism. 2011;2011:7. doi: 10.1155/2011/475216.475216 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
95. Guzik T. J., Sadowski J., Guzik B., et al. Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26(2):333–339. doi: 10.1161/01.atv.0000196651.64776.51. [PubMed] [CrossRef] [Google Scholar]
96. Miatello R., Vázquez M., Renna N., Cruzado M., Zumino A. P., Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. The American Journal of Hypertension. 2005;18(6):864–870. doi: 10.1016/j.amjhyper.2004.12.012. [PubMed] [CrossRef] [Google Scholar]
97. Liu C., Cao F., Tang Q. Z., et al. Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways. Journal of Nutritional Biochemistry. 2010;21(12):1238–1250. doi: 10.1016/j.jnutbio.2009.11.001. [PubMed] [CrossRef] [Google Scholar]
98. Ide N., Lau B. H. S. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-κB activation. Journal of Nutrition. 2001;131(3):1020S–1026S. [PubMed] [Google Scholar]
99. van Doorn M. B. A., Santo S. M. E., Meijer P., et al. Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects. The American Journal of Clinical Nutrition. 2006;84(6):1324–1329. [PubMed] [Google Scholar]
100. Campbell J. H., Efendy J. L., Smith N. J., Campbell G. R. Molecular basis by which garlic suppresses atherosclerosis. Journal of Nutrition. 2001;131(3) [PubMed] [Google Scholar]
101. Sitia S., Tomasoni L., Atzeni F., et al. From endothelial dysfunction to atherosclerosis. Autoimmunity Reviews. 2010;9(12):830–834. doi: 10.1016/j.autrev.2010.07.016. [PubMed] [CrossRef] [Google Scholar]
102. Morihara N., Ide N., Weiss N. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. Journal of Ethnopharmacology. 2011;134(3):711–716. doi: 10.1016/j.jep.2011.01.021. [PubMed] [CrossRef] [Google Scholar]
103. Ried K., Frank O. R., Stocks N. P. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. European Journal of Clinical Nutrition. 2013;67(1):64–70. doi: 10.1038/ejcn.2012.178. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
104. Steiner M., Khan A. H., Holbert D., Lin R. I.-S. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. The American Journal of Clinical Nutrition. 1996;64(6):866–870. [PubMed] [Google Scholar]
105. Reinhart K. M., Coleman C. I., Teevan C., Vachhani P., White C. M. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. Annals of Pharmacotherapy. 2008;42(12):1766–1771. doi: 10.1345/aph.1l319. [PubMed] [CrossRef] [Google Scholar]
106. Ried K., Frank O. R., Stocks N. P. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010;67(2):144–150. doi: 10.1016/j.maturitas.2010.06.001. [PubMed] [CrossRef] [Google Scholar]
107. Budoff M. J., Ahmadi N., Gul K. M., et al. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Preventive Medicine. 2009;49(2-3):101–107. doi: 10.1016/j.ypmed.2009.06.018. [PubMed] [CrossRef] [Google Scholar]
108. Gonen A., Harats D., Rabinkov A., et al. The antiatherogenic effect of allicin: possible mode of action. Pathobiology. 2006;72(6):325–334. doi: 10.1159/000091330. [PubMed] [CrossRef] [Google Scholar]
109. Jain R. C., Konar D. B. Effect of garlic oil in experimental cholesterol atherosclerosis. Atherosclerosis. 1978;29(2):125–129. doi: 10.1016/0021-9150(78)90002-3. [PubMed] [CrossRef] [Google Scholar]
110. Dirsch V. M., Keiss H.-P., Vollmar A. M. Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells. European Journal of Nutrition. 2004;43(1):55–59. doi: 10.1007/s00394-004-0437-7. [PubMed] [CrossRef] [Google Scholar]
111. Hotamisligil G. S. Inflammation and metabolic disorders. Nature. 2006;444(7121):860–867. doi: 10.1038/nature05485. [PubMed] [CrossRef] [Google Scholar]
112. Gregor M. F., Hotamisligil G. S. Inflammatory mechanisms in obesity. Annual Review of Immunology. 2011;29:415–445. doi: 10.1146/annurev-immunol-031210-101322. [PubMed] [CrossRef] [Google Scholar]
113. Lumeng C. N., Deyoung S. M., Bodzin J. L., Saltiel A. R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56(1):16–23. doi: 10.2337/db06-1076. [PubMed] [CrossRef] [Google Scholar]
114. Liu J., Divoux A., Sun J., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nature Medicine. 2009;15(8):940–945. doi: 10.1038/nm.1994. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
115. Ohmura K., Ishimori N., Ohmura Y., et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30(2):193–199. doi: 10.1161/atvbaha.109.198614. [PubMed] [CrossRef] [Google Scholar]
116. Keophiphath M., Priem F., Jacquemond-Collet I., Clément K., Lacasa D. 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. Journal of Nutrition. 2009;139(11):2055–2060. doi: 10.3945/jn.109.105452. [PubMed] [CrossRef] [Google Scholar]
117. D’Elios M. M., Amedei A., Del Prete G. Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma. Microbes and Infection. 2003;5(8):723–730. doi: 10.1016/s1286-4579(03)00114-x. [PubMed] [CrossRef] [Google Scholar]
118. Khosla P., Karan R. S., Bhargava V. K. Effect of garlic oil on ethanol induced gastric ulcers in rats. Phytotherapy Research. 2004;18(1):87–91. doi: 10.1002/ptr.1349. [PubMed] [CrossRef] [Google Scholar]
119. Oommen S., Anto R. J., Srinivas G., Karunagaran D. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. European Journal of Pharmacology. 2004;485(1–3):97–103. doi: 10.1016/j.ejphar.2003.11.059. [PubMed] [CrossRef] [Google Scholar]
120. Kim J. Y., Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims. The American Journal of Clinical Nutrition. 2009;89(1):257–264. doi: 10.3945/ajcn.2008.26142. [PubMed] [CrossRef] [Google Scholar]
121. Suddek G. M. Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals. Pharmaceutical Biology. 2014;52(8):1009–1014. doi: 10.3109/13880209.2013.876053. [PubMed] [CrossRef] [Google Scholar]
122. Miron T., Mironchik M., Mirelman D., Wilchek M., Rabinkov A. Inhibition of tumor growth by a novel approach: in situ allicin generation using targeted alliinase delivery. Molecular Cancer Therapeutics. 2003;2(12):1295–1301. [PubMed] [Google Scholar]
123. Shin D. Y., Kim G.-Y., Hwang H. J., Kim W.-J., Choi Y. H. Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environmental Toxicology and Pharmacology. 2014;37(1):74–83. doi: 10.1016/j.etap.2013.11.002. [PubMed] [CrossRef] [Google Scholar]
124. Xu L., Yu J., Zhai D., et al. Role of JNK activation and mitochondrial bax translocation in allicin-induced apoptosis in human ovarian cancer SKOV3 cells. Evidence-Based Complementary and Alternative Medicine. 2014;2014:6. doi: 10.1155/2014/378684.378684 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
125. Sigounas G., Hooker J., Anagnostou A., Steiner M. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutrition and Cancer. 1997;27(2):186–191. doi: 10.1080/01635589709514523. [PubMed] [CrossRef] [Google Scholar]
126. Amagase H., Milner J. A. Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis. 1993;14(8):1627–1631. doi: 10.1093/carcin/14.8.1627. [PubMed] [CrossRef] [Google Scholar]
I have reported you, not for your opinion, which anyone can see is ignorant and mis informed which you are welocme to indulge yoursef in, but because you are a moron that the public should be protected from, a career at the bbc seems in order for you
Darcy – the reports come to me . I notice that you posted the long reference at 0458 Sunday morning . I’m sure it’s of value to someone . If you want to call people ‘morons ‘ on this site please go find one where such rudeness is more’ the norm’ – also don’t post very bad words which I have to spend time editing . ( it was on one of your night time posts ) .
You refer to rudeness please refer to the poster who called me “idiotic” when i referred to science and logic,
as to your other complaint I can only assume that your reference to the time of the post makes an assumption that night time posts are of less value than daytime well .. we will let that judgement hang
1. Edit down 50 minutes plus of multiple-presenter briefing to just a few minutes of Presidential speculation.
2. Top and tail it with sarcastic voice-over by BBC female.
3. Broadcast it.
4. Wait for response from UK ‘experts’ to BBC News’ made-up-story.
5. Report ‘confirmation’ by UK ‘expert’ that, on the basis of a BBC film designed to make the president look like an idiot, he looked like an idiot.
Or to put it more simply, make up a fake news story, show it to someone with some creditability that trusts you, then report their comments as fact!
That is the equivalent of criminals ‘laundering’ money!
News laundering: The process of feeding a fake news story to a trusted authority so as to get it regenerated as fact.
It takes Politico 11 mins to explain how the bBC deceives the casual viewer using a very short clip of its own manufacture. It is a good example of what the bBC does scores of times a day and why many people have given it up altogether.
I wonder how long the bBC took to engineer their clip, how much plotting and planning and scheming it took, and how much it cost the TAXpayer? How many bBC operatives in total were involved in the deception?
In a just society run by normal people, measures would be taken immediately against:
the bBC – obviously
OfCom – who should have already acted as ‘watchdog’ and seen what Politico saw
Kings College – who apparently hire sub-standard staff
Clearly all three are not fit for purpose and are not acting according to their designated remit(s).
Of course these three are not the only ‘institutions’ that are not fit for purpose.
island -Is Ofcom not stuffed full of former bbc employees, or people with bbc connections? One big, happy family, I gather, as the lack of any action against the wilder beeb propaganda, attests.
Very interesting. However I think he’s being unfair in making out that Trump misunderstood the disinfectant part. It seems to me that Trump was noting the effect of disinfectant on contact and wondering if you could get the same effect by injecting the UV light to make internal contact.
Yes, RD. The President has a poor way with English language as you demonstrated by putting up some of the actual text used in the briefing. Think POTUS was possibly/probably making an instant leap to endoscopy/bronchoscopy because he’s an ‘ideas man’. He’s heard of organ washing and blood washing being done as part of various treatments, including transplants, and floated out an idea because that’s what he likes to do.
I hope this rebounds on the BBC. If I was a journalist wanting to make a name (and probably live dangerously), I’d be looking at links between the BBC and the Democratic Party in America. The BBC are really out to ‘get Trump’ and ‘sink Trump’. In the opposite way to old man Hearst saying to his publications in the early 1950s ‘puff Graham’. He wanted them to publicise and cover Billy Graham’s growing worldwide ministry – and get some sales on the back of it.
Viruses are highly adaptable, and have developed ways to avoid detection by T cells. Some viruses stop MHC molecules from getting to the cell surface to display viral peptides. If this happens, the T cell doesn’t know there’s a virus inside the infected cell.
However, another immune cell specialises in killing cells that have a reduced number of MHC class I molecules on their surface – this cell is a natural killer cell or NK cell for short. When the NK cell finds a cell displaying fewer than normal MHC molecules it releases toxic substances, in a similar way to cytotoxic T cells, which kill the virally-infected cell. https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/immune-responses-viruses
” In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils,” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417560/
Things the bbc syense editor is unlikely to be aware of, or any other of their wurld klass gernaliss, unless, of course, their local mosque instructs 300 muzzies to email them the info
that tends to direct their editorial content, whilst the 85% indigenous population that fund the bbc may as well urinate into a typhoon as expect their voices to be heard, or their interests or concerns represented
RE Easter vs rama bleeding dam
Last week the left came down on Boris but then there's this – Nicola Sturgeon missed six Cobra meetings as virus tightened grip on Scotland!!! https://t.co/hV59AoTTV6
We have it from Neil Ferguson, key member of SAGE – Dominic Cummings observed, but did not get involved in decision-making at SAGE. What’s wrong with that? Good idea he was there to listen and learn? https://t.co/282OKlwoeZ
Regarding my above rant, the point I should really have made is the bbc used the word “fake”, viruses are effective at killing people with lowered immune systems, who is spreading fake news?
My personal recommendation: Vitamin D3, E and C (1000mg) supplements, selenium, garlic capsules and a B complex
Doctors always say a balanced diet etc etc who can manage that when you have to queue to get into a shop ? and to get the above into your diet you would be eating all day
and regarding the mediterranian diet, well thats done them a lot of good has it not, Italian coffin makers are doing well
“Household cleaners and disinfectants can cause health problems when not used properly..
What I find interesting is the thought that it isn’t the job of the media to take it upon themselves to issue warnings about anything because that is the job of the appropriate body of a properly elected government and in this case the CDC
I thought we gave up running when we learnt how to farm a few thousand years ago , especially running when dressed as a chicken / gorilla etc and I am willing to bet none of the hunter gatherers did interviews on the bbc about raising money for their local child minding cave whilst dismembering a mammoth
I could be wrong, I will leave it to the bbc Arkiolgist experts to discuss, I suspect they will find evidence of a neanderthal red nose day somewhere or other with a Lenny Henry ancestor doing funny things with fire
If ever there was evidence of too many BBC journalists these trawls for stories is it. To 99% of us whatever someone is doing instead of running will be plain boring. If someone is doing something interesting, they are too busy doing it and not contacting the BBC.
Hold on, surely Sky wouldn’t commission push polling? It was a Sky/YouGov poll. In any event it was the latest in a number of polls showing the same thing. Loss of confidence in the media. https://t.co/JBf2VeGlHm
FFS – coping!…well judging from where I live they are all meeting up in my street..
My puzzle is why they are saying some years will have to retake a whole year because of what they are missing… Nowadays they have the bloody internet/online teaching – what exactly is the reason they can’t keep up with school work?
Why are the teachers not delivering lesson using Teams or Zoom like we are…
Oh I forgot they are Key workers – duh! only not working. Sorry Rant over…
The second item on the R4 Religion prog
was Muslim advertising agency
Mud Orange – a new ‘creative agency’
launched at the start of this year’s Ramadan
– is, according to its founders,
the first in the Western world to specialise in targeting the Muslim consumer,
while aiming to reshape the public image of Muslims.”
A former Ogilvy PR strategist and a graphic designer have set up an agency, called Mud Orange, with the aim of repositioning the role Muslims play in the industry, as well as how they are portrayed in mainstream advertising https://t.co/G7vli9fWT1pic.twitter.com/4Xuh3Gs3sU
I suspect they will be recruiting architects specialising in tall buildings with flat roofs and suppliers of hole diggers and stones
and publishers of an A to Z of local schools and care homes within easy reach of a Vauxhall Vectra taxi with no MOT that refuses to provide a service to blind people because they hate dogs
I look forward to all those hijab-ed mummies with their black husbands and mixed-race kids buying sofas, eating bacon burgers and celebrating Christmas!
Beeb in full on “No Male Utopia” mode yesterday on their front page. The only pic of a male (white of course) was an illustration of him sending a “revenge porn” video further up. We’re all not that Beeboids, or have you got an agenda?
The government doesn’t make the locations and ages of those poor souls available to the public .
Care Homes deaths – which I suspect are ‘ off the books’ and take weeks to go on the statistics are a horror and will be the scandal that comes out of the handling of this
Can anyone see anyone coming out of this well ? ( apart from anyone who invents the miracle vaccine ) ?
Unfortunately, care homes are businesses, I knew a lady that worked in one a while ago, the smell of urine as I walked in..it takes a certain kind of person that can cope with dying, very ill people at the end of their life, and have lost control of their bowels, I could not, and as a business, without the resources given to the NHS I cannot see how they can cope
There are, particular kinds of people that do that job, I have met a few and they don’t need to be clapped, because if I was one of them I would be saying
“where were you over the last 20 years when I have been looking after people who are dying ?”
There is bugger all going on in A and E and we have time to dance IN PPE wheres the valium cabinet…thats always short for some strange reason
Jeff Goldblum questioned the anti-woman and anti-homosexual nature of many Muslim-majority countries around the world and has now been cancelled by Twitter's left-wing hate mob. Despite the fact many Muslims fled to the USA precisely to leave their religion’s medievalists behind. pic.twitter.com/aLFd2lTRna
‘Views my own’ no defence for opinions shared on Twitter by BBC News staff, updated guidelines state
Previous guidelines said only that a similar disclaimer that retweets do not signify endorsement “may not be enough”.
BBC editorial staff and anyone who identifies “as being linked with the BBC”, have now been formally told that sharing their opinions online or in the press could “compromise the BBC’s impartiality” and “damage its reputation”.
The risk is greater where the public expressions of opinion overlap with the area of the individual’s work,” the guidelines state”
Can you guarantee, Minister that our fleet will not fall off the edge of the earth if it sails too far? and to follow, why have you not paid the families of those lost sailors ?
On Marr this morning (Yes, I subjected myself to some self harm!!)…The next German Ambassador to the UK was asked ‘Why is the German response so much more effective than the UK’s approach’.
His reply was basically One word, TESTING! Aggressive, Test, Trace, Isolate. Then Repeat!
Matt Hancock to Parliament 27th Janaury 2020 stated: “The UK is one of the first countries in the world to have developed an accurate test for this coronavirus and PHE is undertaking continuous refinement of this test. PHE has this morning confirmed to me that it can scale up this test so we are in a position to deal with cases in this country if necessary.”
The BBC’s admiration for Germany stems from two things: (1) it is not Britain and (2) it’s the heart of their beloved EU. We do not yet know the reasons why their response currently *appears* to be more effective. But, one factor might be in the way that deaths are attributed. The Germans are very precise in these matters (‘shot to death’, ‘died in concentration camp’, ‘died during death march’ etc), whereas the British response seems to be along the lines of ‘Had a bit of a cold a few months back? Put the cause down as Covid-19’. Ditto in the US, where there is no longer any burden of proof and it is merely sufficient to say ‘probably’ down to Covid-19 without any testing at all.
I concur with the sycophantic relationship between the BBC, Germany and the EU.
I also agree the German counting is precise. Our teutonic cousins have form here. However, I do not agree with your Perception of the British counting system.
Reports suggest the opposite of what you claim. Doctors are reluctant to add Covid to the Death Cert. And the Care home figures are a complete unknown.
In contrast to that 2 points. I’m not defending the BBC here.
1. Our counting is clearly not precise, potentially bias to under-representation. It’s, therefore, likely to be far higher than the ‘hospital only figures’ presented to us.
2. Matt Hancock lied to Parliament and the nation on January 27th.
Why are the BBC and the media not ‘on this’? Why are the BBC and the Media not ‘on the migrant crossing crisis’? Why are the media not on the ’15K’ people enter our country unchecked every day?
Jugears Marr let the ghastly droning Rachel Reeves drone on without interruption. Nicola Krankie-Sturgeon didn’t give Jugears any information on when he might be allowed to visit his aged parents outside Dundee. Jugears didn’t insist that Krankie give him the precise date and time that he might be so allowed…as he would if it were a Tory minister.
Darcy / Venut,
Am I missing something? You can test all you want but without a cure……… A statisticians wet dream.
Only reason you might extend vetting is if you were 100% sure that a previously infected person could not re-acquire and spread the chinese virus. That’s one of the big unknowns. But, the statisticians have to have their say so for them more more and even more testing is good for their business. Maybe if we follow this rolling snowball downhill and find a staggering number of the population are infected through testing, we might conclude that, that, that, lockdown and isolation is the only safe way……………..
Testing, tracing and isolating. The German,S Korean, Australian etc etc method is clearly successful.
1. Testing shines light. It allows policy to intelligently adapt to what’s happening in the on the ground. At present we have absolutely no idea what the hell is happening or where. Who has it? And precisely where they have it. All we know is patients ‘rock up’ to A+E. generally more in some areas than others. This is not good enough.
Testing sheds light on this and allows policy to, ‘totally lock down’ in say “London’ while keeping a ‘soft Lockdown’ in say Cornwall.
It’s just smart.
2. Community test en masse stops spread. Given many who carry this virus are asymptomatic. You can identify through testing, immediate isolate, trace contacts. Isolate them (and I really mean isolate – not texting your whereabouts every few days) re-test and prevent further spread. This is exactly what S Korea/Austarlia do/did so successfully.
3. While testing is not a cure. If you continually test, then restrictions can be lifted and applied as necessary rather than an entire nation sat in ‘like lemons’ clapping like morons or moaning.
At the minute we do not test. It makes policy blunt, weak and fuzzy.
We all suffer because of our lack of testing. While I hate the BBC, our government is second rate. The response is a joke.
We need ‘war’ leaders, not middle management career politicians. I also include the opposition (and the rest of the joke MPs in parliament) in this group too (for clarification).
Open everything up again. Holiday in this country. Children go back to school, but as they can be the biggest ‘carriers’, make wearing masks and gloves mandatory, treat everyone as though they have the plague and keep the social distancing for 12 months. Hugging and physical contact may be missed, but isn’t it a price worth paying in exchange for not being laid out with a respirator with only a 50/50 chance of surviving ? I certainly can.
Don’t forget all, essential viewing today on al beeb 1 – The 1981 London Marathon: A Historical First! ????
And people pay for this sh*t? ????
I wonder if Jimmy Savile’s fundraising will feature ????
There are lots of pertinent comments and questions attached to the article.
Yesterday I saw a comment from a Royal Marine on twitter saying (I paraphrase) give him a few weeks and the resources and he would have the problem solved. So I say – put the Marines in charge of Border Farce. It’s obvious.
I used to dismiss ‘conspiracy’ theories but it is difficult to ignore the one about deliberate population replacement.
A QUESTION PRITI REFUSES TO ANSWER ? She says she will try to stop it ? Ok I challenge priti , give me all the resources I require and I will stop this flow within weeks ! And once I implement my repel plan no illegals will come via the channel again !
On the military, I remember a thought provoking if skewed movie which had Bruce Willis as a general tasked by panicking pols to address a collapse in civil order due to terrorism. Before taking it on he advises that they won’t like what it takes. They don’t. And I think he gets shafted.
The era of rough men being able to do the jobs others won’t was crushed years ago in every edit suite in the hands of the wrong journalist. Which means every journalist.
I can’t remember where I read it, maybe on here or the DT but several comments have appeared saying that the number of deaths we get in the daily stats are up to 3 weeks old as it takes that time to get all the paperwork and stuff done.
Basically, today’s numbers are those who died on 5 April or thereabouts.
The comments all say that the number of deaths occurring today, yesterday and recently are in the 100’s, still a lot but far better than the 700’s we are being told.
They say (commentators) they have found out these numbers by monitoring nhs sites (or something like that)
I have no idea if these numbers are true but if so it should mean in about 3 weeks we should be having daily rates of 100 or so.
You would think that someone in the media would point this out if there is any substance to it, it’s certainly worth looking at.
My default position is that I cannot believe anything the msm or government say as everything now has an agenda or bias.
I wish the bbc was an impartial news provider but it’s now just the same as the rest, an agenda driven lefty organisation.
Has anyone got any suggestions of an impartial news source?
It is fascinating the Labour party has desperatly tried to create race hatred, the only reason the stabbed Stephen Lawrence came to prominence was because his father worked for a Daily Mail reporter, the absolute plethora of blacks stabbiing around london is ignored
AND another thing, how many wimmin have you seen wandering about in NHS”uniforms” so many around now for some strange reason, hmm they seem to wear them all day long
we have to worship
I have to drive 40 miles three days a week to sort other things out
luckily have never got the clap I understand it is painful
‘I dont dress myself in a blue smock and walk around expecting applause
I have always thought it was a very unclean habit to come out of place of work whether it be a hospital or a nursing home wearing a uniform that’s been used all day attending to sick patients. I still cannot understand how hospitals allow this. I have had same opinion even before this outbreak. I’ve always maintained they should go in their own clothes, change when they are there and bring back dirty uniform in carrier bag for washing. These same staff just wander into supermarkets or sit next to people on public transport. I dont know why this hasnt been picked up by hospital admin.
cromwell
Agree entirely. We do not have a car and rely on buses, which are often crowded, and regularly see health workers/nurses travelling in uniform.
I suppose if they are required to travel in their own clothes there will be a call from certain quarters for a substantial ‘clothing allowance’.
Back when there were ‘proper’ matrons and nurses homes, they wouldn’t be allowed in public in uniform, AND they had to look pristine clean on duty – sadly lacking now. Equally you often see operating operatives with flapping gowns, head gear and masks roaming free in the hospital – whats that all about ? White coats have gone, so anyone with a stethoscope around their neck could be examining you. Our ‘progressive’ NHS for you.
Brissles, we used to see nurses out and about in London …
… but ….
they would be wearing caps and capes or cloaks in winter and were always immaculate.
Seem to recall from my time ‘in the slammer’ sorry, hospital as a kid, that Matron or a Ward Sister would inspect the nurses coming on duty, much as a British Police Station Sergeant would hold a line up of Constables before they went on duty.
Richard Dawkins is great
but has tweeted stuff like this
7 March : Denying evolution & climate change,
denying that smoking kills
& condoms protect against AIDS,
denying science again & again,
Pence’s track record in the world of facts
would naturally make him Trump’s top choice
to lead the fight against an epidemic
links to Newsweek article https://t.co/KSKTUjJ9g4
Then former beeboid Gavin Esler retweets
& adds sneers at the Climate Realists cos they are so inferior to him. Is it at all possible @richarddawkins
that the coronavirus outbreak might persuade
anti-vaxxers, climate change deniers and other flat-Earthers
that science, knowledge, facts,
Enlightenment values and experts are actually useful?
Esler is misrepresenting Climate Change Realists, and doing false analogy to smear them.
cos of course such Realists do respect “enlightenment values”, proper science, proper scientific method
fact-not-speculation
& not having certainty beyond the available evidence etc.
With the world going to hell in a handbasket, how reassuring that the beeb still find the time and space and (your) money to report on a tranny in a long, long, long piece of agitprop – sorry, ‘article’. Complete with undertones of antisemitism.
“Ultra-Orthodox and trans: ‘I prayed to God to make me a girl'” https://www.bbc.co.uk/news/stories-51928077
DeborahNov 22, 23:08 Weekend 23rd November 2024 Lefty, I know the green blob may have changed to ‘climate change’ to cover all eventualities but people still know…
BigBrotherCorporationNov 22, 22:43 Weekend 23rd November 2024 I thought the BBC were giving X the cold shoulder, because of Musk supporting Trump?
Guest WhoNov 22, 22:21 Weekend 23rd November 2024 https://x.com/bbcnews/status/1860028485890105443?s=61 Farming tax row – BBC Verify on which figures are more reliable and why Once folk have stopped laughing……
Fedup2Nov 22, 22:09 Weekend 23rd November 2024 Outrageous – BBC. Reports that the sentencing of Donald trump – an already convicted Felon – for a white collar…
atlas_shruggedNov 22, 21:16 Midweek 20th November 2024 The French want to kick the British border check out of Calais so that they can just send the invaders…
Lefty WrightNov 22, 21:12 Weekend 23rd November 2024 Flotsam Don’t tell anyone but we don’t refer to global warming any more. in New Speak we have to refer…
Fedup2Nov 22, 21:09 Midweek 20th November 2024 Really vexed . The truth about Rachel Reeves insolvent with the Bank of England is coming out now ….. but…
The idea that Covid19 kills more blacks
especially Caribbeans
Victoria Derbyshire tweeted it straight away
To me there is an obvious error in the data
Where is the white-non-British ?
..there are supposed to be 2million Poles plus loads of Romanians plus loads of East Europeans etc.
a table published in article by Andrew Norfolk in @TheTimes
shows that in terms of #Covid_19 hospital deaths,
black Caribbean communities have 70 deaths per 100,000
normal blacks 48
almost all ethnic groups have higher mortality rates than white British.
(well only cos they separate out Pakistani and Bangladeshi)
https://www.thetimes.co.uk/article/black-coronavirus-patients-are-dying-at-double-the-rate-of-white-in-hospitals-lddtfs6vz
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Even starker data for worker deaths
– nurses/midwives 71% BAME
– doctors/dentists* 94%
– healthcare support workers 56%
ah the data set is EXTREMELY small just 106 people
38 of whom were white
64 were born outside UK
* FFS only 1 dentist + 1 dental worker
ONLY 4 of the BAME were born in the UK
The sex ratio is strange
52F 48M
I guess medics are mostly female
London/SE account for 47%
It seems PPE worked; none of the dead medical staff worked in ICU.
https://www.hsj.co.uk/exclusive-deaths-of-nhs-staff-from-covid-19-analysed/7027471.article
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Was she not once a Newsnightie?
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A thread about possible corruption in the Oldham Labour Party establishment
.. i cannot vouch for any of it
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hmm, no likes.. Try opening up the tweets near the top
here
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I live in Oldham and this story has been trying to get out for ages but has been continually suppressed by MSM.
It seems that Muslim grooming gangs have been operating in Oldham for decades but the authorities have kept it quiet.
The ringleader of the Rochdale gang was convicted and imprisoned but what was not publicised was that he was employed by Oldham council as a youth worker.
A bloke named Raja Miah has been investigating and putting things on social media and been subject to regular death threats from an out of control muzzie community.
It is alleged that the now labour MP Jim McMahon (who was at the relevant time chief executive of Oldham council) was complicit in a cover up of a story involving mass grooming and rape of underaged local white kids by Muslim gangs in unused commercial premises where they set up unlicensed shisha bars etc.
An email was published where a local bbc reporter was asked by McMahon not to publish the story because it might inflame tensions on the day of Lee Rugby’s funeral. McMahon promised cooperation when the heat of the Lee Rigby situation subsided. The story has never since been aired. It should be a national scandal.
There is so much more evidence of a Muslim
takeover of the oldham Labour Party and the plan to islamify this once proud town that is far too voluminous to summarise here.
Councillors and advisers to McMahon are allegedly mixed up on all kinds of dodgy stuff from buying council land cheap to build mosques to employing convicted drug dealers and loads more besides.
If you google “raja miah, recuscient nine” it will keep you busy for hours and make your blood boil.
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I wonder what extinction rebellion and the far left have to say about the force of nature,,precisely nothing
Because nature has decided to eliminate:
the morbidly obese
those who refuse to self isolate because they have no respect for the law
those who refuse to self isolate because they think their culture is above the law
apparently nature is racist so a labour government will ban nature
No doubt with saint Stephen Lawrence’s second cousin as cabinet minister in charge
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Not the bbc, but a fascinating media timeline.
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But, hey, milk has to be milked…
BBC News
Doctors have warned that heeding the US president’s comments on using disinfectants or UV light to treat coronavirus could have fatal consequences.
bbc.in/3cNjX6Z
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And as light follows heat…
http://isthebbcbiased.blogspot.com/2020/04/trusting-media.html
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That headline must be so fake news
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The kind of individual that velcro was invented for to save him 10 minutes putting his shoes on
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10pm BBC1 news Saturday night and breaking news according to the Asian girl reading it. Boris is back to work on Monday. How much does the news people cost us licence payers (I know we should stop)? What are those 450 people they are keeping on doing? I am sure either here, the DM or Guido told me yesterday that Boris would be back at work on Monday.
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Deborah – Expect in depth analysis on what Boris’s return will mean!
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BBCnews are 48 hours late
The Telegraph had it at 9:30pm on Thursday
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Kuenssberg studied history at the University of Edinburgh, followed by a journalism course at Georgetown University in Washington, D.C.,[where she worked on an NBC News political programme.
Which, apparently, qualifies her to attack the government on all fronts from logistics to science, what an education she must have recieved
Studied ? generally means chucked out and did not qualify, hmm I’ve studied nuclear physics (read a book)
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Anyone heard from Terry Christian lately?
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Picture fail. Tries again. Looks like it will fail again. Gives up trying. Goodnight.
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this is that image
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StewGreen – Thanks. How did you do that? What did I do wrong?
Do you work for the Russians?????
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I didn’t do anything special
I just picked up the image and clicked the
“add images” link that is is 2cm below the Post Comment button
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Has anyone esle noticed the complete and utter lack of qualifications of bbc journalists to be qualified about what they talk ? any search will do just google the uneducated bunch
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One doesn’t have to be educated
Take he small boy in the tale of the Emperor’s new suit.
However one can be diseducated like the lying courtesans and our lying agenda pushing media in their fantasy world.
These days old grannies and truck drivers ask better questions than the Oxbridge journos.
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R4 – Monbiot and friends discuss the future. Lotsa professors with Mary Ann Seekheart (?)
Climate change: Nice things about China, but not the bad USA. The elderly are leaving the youth with a bad heritage. Blah, blah. Apparently the old fogies are not with the ‘Zeitgeist’; very intellectual stuff.
Same old, same old. Waiting for the Quiz is hardly worthwhile…
News says Border Farce have ‘stopped’ three boatloads of ‘migrants’. By taking them to Dover. Where they were tested for Coronavirus. That’s the way to do it if you can’t get a test!
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It’s a repeat I commented on Monday/Tuesday morning
i caught her fawning tweet about Figueres
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Apparently mosques are being hit by the Chinese virus, as no visitors = no donations.
Boo hoo, I’m heartbroken, but take comfort in the fact they will no doubt be begging for public subsidies, which the supine authorities will be only too wiling to grant.
Meanwhile it is reported that the authorities in various European countries have turned a blind eye to illegal Ramavan gatherings.
https://barenakedislam.com/2020/04/25/hey-everyone-its-ramadamadingdong-which-means-for-muslims-covid-19-restrictions-need-not-apply/
https://barenakedislam.com/2020/04/23/uk-a-little-good-news-on-the-first-day-of-ramadan/
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Oh, dear. Poor Mr Innocent Sopel is upset that Donald Trump might not do any more briefings following the media’s porkies about disinfectant.
For those who may not have seen it, here is a fuller transcript of what was being talked about that led to the now infamous remarks.
It’s quite clear. He was talking about ultra violet light and whether there was some way to inject it into the body. The ‘disinfectant’ is presumably a reference to properties of the the UV light itself.
Sopel knows this, as he refers in an earlier tweet to the existence online of these transcripts where he is using it to (in his own mind) catch the President out. So he must have read it, and is happy to carry on lying.
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Roland
Thanks for that – I shall go shove it up the rear end of a few people I know..it won’t see much light but they will get a good cleaning.
Anyone with a brain could see he was just raising ideas – based on existing work..
You just have to hope somebody reports the BBC for misrepresentation and fake news.
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It really won’t do you any good. I broke the habit of a lifetime and responded to someone who had replied to my comment on Twitter to Mr Sopel. I was trying to get to the root of why he thought the President had suggested injecting disinfectant.
It remained civil and I quote from part of the last response (to date): “there can be no ambiguity that his thought process was that testing on direct injection of disinfectant was possible”.
There’s no arguing or reasoning with a mindset that believes they can read thoughts. Context doesn’t matter when you are a mind reader. I will not be engaging further. There is no point, and even if I had changed his mind it would be one person amongst the millions – no, billions that the media has manipulated.
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Roland – I monitor twitter now – more so because I have largely excluded the BBC from my life – I have never ‘twittered ‘ and never will – nor uptick or retweet .
I think a big element of entrenched views just shouting at each other – and there are people called FTBE or similar which seems to be some ‘Remainer ‘ club …..
The funny stuff can be good though – but I’ve stopped looking at the comments because there are a lot of people with no sense of humour .
As for this site – the chinese virus – as I suppose is inevitable – has taken over . But the site is a lot busier which is good and still fairly troll free ….
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Cummings attended a meeting and Al Beeb are worried, but what are they worried about?
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Taffman – I think the BBC is concerned about the composition of SAGE – are blacks and Pakistanis and queer types adequately represented . Also – why isn’t it broadcasted on live TV in a ‘dancing format ‘ with a compare and studio audience ?
Sometimes it’s a bit desperate isn’t it ….. ?
new thread going up shortly ……
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Tucker on Biden’s #MeToo from 1993
that CNN couldn’t find even though it was on a CNN show.
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In a country in which white people make up 96% of the population, why is it that the BBC invariably uses images of BAME people (mostly women) to illustrate Scotland-specific pieces relating to Covid-19?
Answers on a (non-alcoholic) beer mat to the usual address.
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ahem bbc et al
immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Rodrigo Arreola, 1 , * Saray Quintero-Fabián, 2 Rocío Ivette López-Roa, 3 Enrique Octavio Flores-Gutiérrez, 4 Juan Pablo Reyes-Grajeda, 5 Lucrecia Carrera-Quintanar, 6 and Daniel Ortuño-Sahagún 6 , *
Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.
Go to:
Abstract
The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences in final composition and compound proportion. In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils, by mechanisms including modulation of cytokine secretion, immunoglobulin production, phagocytosis, and macrophage activation. Finally, because immune dysfunction plays an important role in the development and progress of several diseases, we critically examined immunoregulation by garlic extracts and compounds isolated, which can contribute to the treatment and prevention of pathologies such as obesity, metabolic syndrome, cardiovascular disorders, gastric ulcer, and even cancer. We concluded that A. sativum modulates cytokine secretion and that such modulation may provide a mechanism of action for many of their therapeutic effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417560/
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C_M,
On one of the previous MedCram videos (sorry, cannot cite the edition number), he refers quite extensively to research into hot baths. Viral infection produces fever. That fever is the body’s natural defences at work and it is recommended that a patient lives with the fever, provided it does not become serious, as to reduce it, artificially stifles the body’s ability to naturally combat the virus. I recall that the researchers found that hot (followed by cold) was beneficial. More research is taking place.
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“the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system”
maybe lara c and the rest of this partially educated shower of sh@t missed that one, or more likely does not understand, her national certificate in basketweaving probably does not cover what the immune system is
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Garlic has been known about for a long time as has echinacea. Another one that comes to mind is feverfew. There is a branch of medicine called pharmacognosy (alt. non-Microsoft, proper English spelling pharmacognacy) and it is as old as the hills, well as old – at least – as Biblical times. Good old aspirin is made from old cricket bats or something similar.
Thanks to a ‘still in date’ highly discounted offer of garlic stuffed olives the Snuffy household became rather interested in same. Not always up for buying the expensive ones that come with feta cheese at Tesco but there are alternatives available. When left to steep in olive oil, they become truly delicious in my view, likewise the bare cloves.
Don’t do what some silly person did when garlic was first mentioned as a boost to the immune system and buy a heap of garlic and eat it in one go. She, iirc, ended up with burns to her esophagus and the top of her stomach. Garlic can be an intestinal irritant.
Warning over, since eating a garlic stuffed olive (or two) a day, maybe with half a clove, I’ve found I have had less colds and less severe colds than previously. To trial thoroughly, I should give up for a couple of years. Unfortunately, I am now hooked, an addict. The olive oil may possibly be more effective, too, than the cod liver oil was at helping my creaking joints.
If you are worried about the smell on breath in times of non-social distancing, don’t. I haven’t lost any friends. And you can buy odour free garlic pills at health food stores and pharmacies. But, BUT ALWAYS, read and follow the instructions, do not exceed the dosage and if you have a pre-existing health condition, check with your GP or a pharmacist first.
As it is the Sabbath, a quote from Scripture: Revelation 22 vs. 1-4.
And he shewed me a pure river of water of life, clear as crystal, proceeding out of the throne of God and of the Lamb. In the midst of the street of it, and on either side of the river, was there the tree of life, which bare twelve manner of fruits, and yielded her fruit every month: and the leaves of the tree were for the healing of the nations. And there shall be no more curse: but the throne of God and of the Lamb shall be in it; and his servants shall serve him: And they shall see his face; and his name shall be in their foreheads.
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References
1. Salman H., Bergman M., Bessler H., Punsky I., Djaldetti M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. International Journal of Immunopharmacology. 1999;21(9):589–597. doi: 10.1016/s0192-0561(99)00038-7. [PubMed] [CrossRef] [Google Scholar]
2. Reinhart K. M., Talati R., White C. M., Coleman C. I. The impact of garlic on lipid parameters: a systematic review and meta-analysis. Nutrition Research Reviews. 2009;22(1):39–48. doi: 10.1017/s0954422409350003. [PubMed] [CrossRef] [Google Scholar]
3. Eilat-Adar S., Sinai T., Yosefy C., Henkin Y. Nutritional recommendations for cardiovascular disease prevention. Nutrients. 2013;5(9):3646–3683. doi: 10.3390/nu5093646. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
4. Khatua T. N., Adela R., Banerjee S. K. Garlic and cardioprotection: insights into the molecular mechanisms. Canadian Journal of Physiology and Pharmacology. 2013;91(6):448–458. doi: 10.1139/cjpp-2012-0315. [PubMed] [CrossRef] [Google Scholar]
5. Fridman S., Sinai T., Zilberg D. Efficacy of garlic based treatments against monogenean parasites infecting the guppy (Poecilia reticulata (Peters)) Veterinary Parasitology. 2014;203(1-2):51–58. doi: 10.1016/j.vetpar.2014.02.002. [PubMed] [CrossRef] [Google Scholar]
6. Amagase H., Petesch B. L., Matsuura H., Kasuga S., Itakura Y. Intake of garlic and its bioactive components. Journal of Nutrition. 2001;131(supplement 3):955s–962s. [PubMed] [Google Scholar]
7. Sivam G. P. Protection against Helicobacter pylori and other bacterial infections by garlic. Journal of Nutrition. 2001;131(3):1106s–1108s. [PubMed] [Google Scholar]
8. Lawson L. D., Gardner C. D. Composition, stability, and bioavailability of garlic products used in a clinical trial. Journal of Agricultural and Food Chemistry. 2005;53(16):6254–6261. doi: 10.1021/jf050536. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
9. Sivam G. P., Lampe J. W., Ulness B., Swanzy S. R., Potter J. D. Helicobacter pylori—in vitro susceptibility to garlic (Allium sativum) extract. Nutrition and Cancer. 1997;27(2):118–121. doi: 10.1080/01635589709514512. [PubMed] [CrossRef] [Google Scholar]
10. Jonkers D., Sluimer J., Stobberingh E. Effect of garlic on vancomycin-resistant enterococci. Antimicrobial Agents and Chemotherapy. 1999;43(12):p. 3045. [PMC free article] [PubMed] [Google Scholar]
11. Gharavi M. J., Nobakht M., Khademvatan S., Fani F., Bakhshayesh M., Roozbehani M. The effect of aqueous garlic extract on interleukin-12 and 10 levels in Leishmania major (MRHO/IR/75/ER) infected macrophages. Iranian Journal of Public Health. 2011;40(4):105–111. [PMC free article] [PubMed] [Google Scholar]
12. Gharavi M., Nobakht M., Khademvatan S., Bandani E., Bakhshayesh M., Roozbehani M. The effect of garlic extract on expression of INFγ and inos genes in macrophages infected with Leishmania major . Iranian Journal of Parasitology. 2011;6(3):74–81. [PMC free article] [PubMed] [Google Scholar]
13. Gorinstein S., Leontowicz M., Leontowicz H., et al. Supplementation of garlic lowers lipids and increases antioxidant capacity in plasma of rats. Nutrition Research. 2006;26(7):362–368. doi: 10.1016/j.nutres.2006.06.008. [CrossRef] [Google Scholar]
14. Sharma A. K., Munajjam A., Vaishnav B., et al. Involvement of adenosine and standardization of aqueous extract of garlic (Allium sativum Linn.) on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury. Journal of Biomedical Research. 2012;26(1):24–36. doi: 10.1016/s1674-8301(12)60004-9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
15. Durak I., Kavutcu M., Aytaç B., et al. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. Journal of Nutritional Biochemistry. 2004;15(6):373–377. doi: 10.1016/j.jnutbio.2004.01.005. [PubMed] [CrossRef] [Google Scholar]
16. Yoshida H., Katsuzaki H., Ohta R., et al. Antimicrobial activity of the thiosulfinates isolated from oil-macerated garlic extract. Bioscience, Biotechnology and Biochemistry. 1999;63(3):591–594. doi: 10.1271/bbb.63.591. [PubMed] [CrossRef] [Google Scholar]
17. Lawson L. D., Wood S. G., Hughes B. G. HPLC analysis of allicin and other thiosulfinates in garlic clove homogenates. Planta Medica. 1991;57(3):263–270. doi: 10.1055/s-2006-960087. [PubMed] [CrossRef] [Google Scholar]
18. O’Gara E. A., Hill D. J., Maslin D. J. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori . Applied and Environmental Microbiology. 2000;66(5):2269–2273. doi: 10.1128/aem.66.5.2269-2273.2000. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
19. Yoshida H., Iwata N., Katsuzaki H., et al. Antimicrobial activity of a compound isolated from an oil-macerated garlic extract. Bioscience, Biotechnology and Biochemistry. 1998;62(5):1014–1017. doi: 10.1271/bbb.62.1014. [PubMed] [CrossRef] [Google Scholar]
20. Aboelhadid S. M., Kamel A. A., Arafa W. M., Shokier K. A. Effect of Allium sativum and Allium cepa oils on different stages of Boophilus annulatus . Parasitology Research. 2013;112(5):1883–1890. doi: 10.1007/s00436-013-3344-0. [PubMed] [CrossRef] [Google Scholar]
21. Liu C. T., Su H. M., Lii C. K., Sheen L.- Y. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica. 2009;75(3):205–210. doi: 10.1055/s-0028-1088396. [PubMed] [CrossRef] [Google Scholar]
22. Shih P.-C., Kuo C.-H., Juang J.-Y., Liu C.-H., Hsu L., Liu C.-T. Effects of garlic oil on the migration of neutrophil-like cell studied by using a chemotactic gradient labchip. Journal of Biomedicine and Biotechnology. 2010;2010:9. doi: 10.1155/2010/319059.319059 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
23. Lee E. N., Choi Y. W., Kim H. K., et al. Chloroform extract of aged black garlic attenuates TNF-α-induced ROS generation, VCAM-1 expression, NF-κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells. Phytotherapy Research. 2011;25(1):92–100. doi: 10.1002/ptr.3230. [PubMed] [CrossRef] [Google Scholar]
24. Park C., Park S., Chung Y. H., et al. Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells. Nutrition Research and Practice. 2014;8(2):132–137. doi: 10.4162/nrp.2014.8.2.132. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
25. Kim S. R., Jung Y. R., An H. J., et al. Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling. PLoS ONE. 2013;8(9) doi: 10.1371/journal.pone.0073877.e73877 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
26. Imai J., Ide N., Nagae S., Moriguchi T., Matsuura H., Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Medica. 1994;60(5):417–420. doi: 10.1055/s-2006-959522. [PubMed] [CrossRef] [Google Scholar]
27. Borek C. Antioxidant health effects of aged garlic extract. Journal of Nutrition. 2001;131(3):1010S–1015S. [PubMed] [Google Scholar]
28. Badr G. M., Al-Mulhim J. A. The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats. Evidence-Based Complementary and Alternative Medicine. 2014;2014:9. doi: 10.1155/2014/759642.759642 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
29. Uda N., Kashimoto N., Sumioka I., Kyo E., Sumi S.-I., Fukushima S. Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. Journal of Nutrition. 2006;136(3, supplement):855s–860s. [PubMed] [Google Scholar]
30. Quintero-Fabián S., Ortuño-Sahagún D., Vázquez-Carrera M., López-Roa R. I. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators of Inflammation. 2013;2013:11. doi: 10.1155/2013/381815.381815 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
31. Makris A., Thornton C. E., Xu B., Hennessy A. Garlic increases IL-10 and inhibits TNFα and IL-6 production in endotoxin-stimulated human placental explants. Placenta. 2005;26(10):828–834. doi: 10.1016/j.placenta.2004.10.019. [PubMed] [CrossRef] [Google Scholar]
32. Keiss H.-P., Dirsch V. M., Hartung T., et al. Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-κB activity. Journal of Nutrition. 2003;133(7):2171–2175. [PubMed] [Google Scholar]
33. Kang N. S., Moon E. Y., Cho C. G., Pyo S. Immunomodulating effect of garlic component, allicin, on murine peritoneal macrophages. Nutrition Research. 2001;21(4):617–626. doi: 10.1016/S0271-5317(01)00269-X. [CrossRef] [Google Scholar]
34. Feng Y., Zhu X., Wang Q., et al. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malaria Journal. 2012;11, article 268 doi: 10.1186/1475-2875-11-268. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
35. Hanieh H., Narabara K., Piao M., Gerile C., Abe A., Kondo Y. Modulatory effects of two levels of dietary Alliums on immune response and certain immunological variables, following immunization, in White Leghorn chickens. Animal Science Journal. 2010;81(6):673–680. doi: 10.1111/j.1740-0929.2010.00798.x. [PubMed] [CrossRef] [Google Scholar]
36. Washiya Y., Nishikawa T., Fujino T. Enhancement of intestinal IgA production by ajoene in mice. Bioscience, Biotechnology and Biochemistry. 2013;77(11):2298–2301. doi: 10.1271/bbb.130408. [PubMed] [CrossRef] [Google Scholar]
37. Kyo E., Uda N., Kasuga S., Itakura Y. Immunomodulatory effects of aged garlic extract. Journal of Nutrition. 2001;131(3):1075s–1079s. [PubMed] [Google Scholar]
38. Zare A., Farzaneh P., Pourpak Z., et al. Purified aged garlic extract modulates allergic airway inflammation in Balb/c mice. Iranian Journal of Allergy, Asthma and Immunology. 2008;7(3):133–141. [PubMed] [Google Scholar]
39. Clement F., Pramod S. N., Venkatesh Y. P. Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. International Immunopharmacology. 2010;10(3):316–324. doi: 10.1016/j.intimp.2009.12.002. [PubMed] [CrossRef] [Google Scholar]
40. Trio P. Z., You S., He X., He J., Sakao K., Hou D.-X. Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food & Function. 2014;5(5):833–844. doi: 10.1039/c3fo60479a. [PubMed] [CrossRef] [Google Scholar]
41. Jones M. G., Hughes J., Tregova A., Milne J., Tomsett A. B., Collin H. A. Biosynthesis of the flavour precursors of onion and garlic. Journal of Experimental Botany. 2004;55(404):1903–1918. doi: 10.1093/jxb/erh138. [PubMed] [CrossRef] [Google Scholar]
42. Augusti K. T., Jose R., Sajitha G. R., Augustine P. A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in Allium products as ideal agents: a review. Indian Journal of Clinical Biochemistry. 2012;27(1):6–20. doi: 10.1007/s12291-011-0146-y. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
43. Ichikawa M., Ryu K., Yoshida J., et al. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. BioFactors. 2002;16(3-4):57–72. doi: 10.1002/biof.5520160302. [PubMed] [CrossRef] [Google Scholar]
44. Ichikawa M., Yoshida J., Ide N., Sasaoka T., Yamaguchi H., Ono K. Tetrahydro-β-carboline derivatives in aged garlic extract show antioxidant properties. Journal of Nutrition. 2006;136(3, supplement):726s–731s. [PubMed] [Google Scholar]
45. Chandrashekar P. M., Prashanth K. V. H., Venkatesh Y. P. Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract. Phytochemistry. 2011;72(2-3):255–264. doi: 10.1016/j.phytochem.2010.11.015. [PubMed] [CrossRef] [Google Scholar]
46. Mahima, Rahal A., Deb R., et al. Immunomodulatory and therapeutic potentials of herbal, traditional/indigenous and ethnoveterinary medicines. Pakistan Journal of Biological Sciences. 2012;15(16):754–774. doi: 10.3923/pjbs.2012.754.774. [PubMed] [CrossRef] [Google Scholar]
47. Spelman K., Burns J. J., Nichols D., Winters N., Ottersberg S., Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative Medicine Review. 2006;11(2):128–150. [PubMed] [Google Scholar]
48. You S., Nakanishi E., Kuwata H., et al. Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators. Molecular Nutrition & Food Research. 2013;57(11):2049–2060. doi: 10.1002/mnfr.201200843. [PubMed] [CrossRef] [Google Scholar]
49. Fu E., Tsai M.-C., Chin Y.-T., et al. The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor-kappa B activation in human gingival fibroblasts. Journal of Periodontal Research. 2014 doi: 10.1111/jre.12217. [PubMed] [CrossRef] [Google Scholar]
50. Ho C. Y., Weng C. J., Jhang J. J., Cheng Y. T., Huang S. M., Yen G. C. Diallyl sulfide as a potential dietary agent to reduce TNFalpha- and histamine-induced proinflammatory responses in A7r5 cells. Molecular Nutrition and Food Research. 2014;58(5):1069–1078. doi: 10.1002/mnfr.201300617. [PubMed] [CrossRef] [Google Scholar]
51. Jafari R. A., Jalali M. R., Ghorbanpoor M., Saraei S. M. R. Effect of dietary garlic on immune response of broiler chicks to live newcastle disease vaccine. Pakistan Journal of Biological Sciences. 2008;11(14):1848–1851. doi: 10.3923/pjbs.2008.1848.1851. [PubMed] [CrossRef] [Google Scholar]
52. Shibasaki M., Sumazaki R., Isoyama S., Takita H. Interaction of lectins with human IgE: IgE-binding property and histamine-releasing activity of twelve plant lectins. International Archives of Allergy and Immunology. 1992;98(1):18–25. doi: 10.1159/000236160. [PubMed] [CrossRef] [Google Scholar]
53. Gupta A., Sandhu R. S. Mitogenic activity of high molecular weight mannose specific agglutinin. Indian Journal of Biochemistry and Biophysics. 1996;33(4):325–327. [PubMed] [Google Scholar]
54. Vogt L., Meyer D., Pullens G., et al. Immunological properties of inulin-type fructans. Critical Reviews in Food Science and Nutrition. 2015;55(3):414–436. doi: 10.1080/10408398.2012.656772. [PubMed] [CrossRef] [Google Scholar]
55. Watzl B., Girrbach S., Roller M. Inulin, oligofructose and immunomodulation. British Journal of Nutrition. 2005;93:S49–S55. doi: 10.1079/BJN20041357. [PubMed] [CrossRef] [Google Scholar]
56. Chen S., Tang Y., Qian Y., et al. Allicin prevents H2O2-induced apoptosis of HUVECs by inhibiting an oxidative stress pathway. BMC Complementary and Alternative Medicine. 2014;14(1, article 321) doi: 10.1186/1472-6882-14-321. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
57. Xu Y.-S., Feng J.-G., Zhang D., et al. S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro. Acta Pharmacologica Sinica. 2014;35(2):267–274. doi: 10.1038/aps.2013.176. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
58. Bauer D., Mazzio E., Soliman K. F., et al. Diallyl disulfide inhibits TNFα-induced CCL2 release by MDA-MB-231 cells. Anticancer Research. 2014;34(6):2763–2770. [PMC free article] [PubMed] [Google Scholar]
59. Park S. Y., Seetharaman R., Ko M. J., et al. Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. International Immunopharmacology. 2014;19(2):253–261. doi: 10.1016/j.intimp.2014.01.017. [PubMed] [CrossRef] [Google Scholar]
60. Hodge G., Hodge S., Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry. 2002;48(4):209–215. doi: 10.1002/cyto.10133. [PubMed] [CrossRef] [Google Scholar]
61. Oft M. IL-10: master switch from tumor-promoting inflammation to antitumor immunity. Cancer Immunology Research. 2014;2(3):194–199. doi: 10.1158/2326-6066.cir-13-0214. [PubMed] [CrossRef] [Google Scholar]
62. Gazzinelli R. T., Oswald I. P., James S. L., Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ- activated macrophages. Journal of Immunology. 1992;148(6):1792–1796. [PubMed] [Google Scholar]
63. Shin I. S., Hong J., Jeon C. M., et al. Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression. Food and Chemical Toxicology. 2013;62:506–513. doi: 10.1016/j.fct.2013.09.012. [PubMed] [CrossRef] [Google Scholar]
64. Yi X., Feng F., Xiang Z., Ge L. The effects of allitridin on the expression of transcription factors T-bet and GATA-3 in mice infected by murine cytomegalovirus. Journal of Medicinal Food. 2005;8(3):332–336. doi: 10.1089/jmf.2005.8.332. [PubMed] [CrossRef] [Google Scholar]
65. Li Y.-N., Huang F., Liu X.-L., et al. Allium sativum-derived allitridin inhibits treg amplification in cytomegalovirus infection. Journal of Medical Virology. 2013;85(3):493–500. doi: 10.1002/jmv.23480. [PubMed] [CrossRef] [Google Scholar]
66. Ebrahimi M., Hassan Z. M., Mostafaie A., Mehrjardi N. Z., Ghazanfari T. Purified protein fraction of garlic extract modulates cellular immune response against breast transplanted tumors in BALB/c mice model. Cell Journal. 2013;15(1):65–74. [PMC free article] [PubMed] [Google Scholar]
67. Sela U., Ganor S., Hecht I., et al. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004;111(4):391–399. doi: 10.1111/j.0019-2805.2004.01841.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
68. Morioka N., Sze L. L., Morton D. L., Irie R. F. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunology Immunotherapy. 1993;37(5):316–322. doi: 10.1007/BF01518454. [PubMed] [CrossRef] [Google Scholar]
69. Nantz M. P., Rowe C. A., Muller C. E., Creasy R. A., Stanilka J. M., Percival S. S. Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clinical Nutrition. 2012;31(3):337–344. doi: 10.1016/j.clnu.2011.11.019. [PubMed] [CrossRef] [Google Scholar]
70. Hassan Z. M., Yaraee R., Zare N., Ghazanfari T., Nejad A. H. S., Nozari B. Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity. International Immunopharmacology. 2003;3(10-11):1483–1489. doi: 10.1016/S1567-5769(03)00161-9. [PubMed] [CrossRef] [Google Scholar]
71. Ishikawa H., Saeki T., Otani T., et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. Journal of Nutrition. 2006;136(3, supplement):816S–820S. [PubMed] [Google Scholar]
72. Kyo E., Uda N., Suzuki A., et al. Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine. 1998;5(4):259–267. doi: 10.1016/S0944-7113(98)80064-0. [PubMed] [CrossRef] [Google Scholar]
73. Banchereau J., Briere F., Caux C., et al. Immunobiology of dendritic cells. Annual Review of Immunology. 2000;18:767–811. doi: 10.1146/annurev.immunol.18.1.767. [PubMed] [CrossRef] [Google Scholar]
74. Ahmadabad H. N., Hassan Z. M., Safari E., Bozorgmehr M., Ghazanfari T., Moazzeni S. M. Evaluation of the immunomodulatory effect of the 14kDa protein isolated from aged garlic extract on dendritic cells. Cellular Immunology. 2011;269(2):90–95. doi: 10.1016/j.cellimm.2011.02.005. [PubMed] [CrossRef] [Google Scholar]
75. Park J. J., Lee J., Kim M. A., Back S. K., Hong S. K., Na H. S. Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1. Neuroscience Letters. 2007;411(2):87–91. doi: 10.1016/j.neulet.2006.10.046. [PubMed] [CrossRef] [Google Scholar]
76. Ghazanfari T., Hassan Z. M., Ebrahimi M. Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. International Immunopharmacology. 2002;2(11):1541–1549. doi: 10.1016/S1567-5769(02)00052-8. [PubMed] [CrossRef] [Google Scholar]
77. Kao S. H., Hsu C. H., Su S. N., Hor W. T., Chang T W. H., Chow L. P. Identification and immunologic characterization of an allergen, alliin lyase, from garlic (Allium sativum) Journal of Allergy and Clinical Immunology. 2004;113(1):161–168. doi: 10.1016/j.jaci.2003.10.040. [PubMed] [CrossRef] [Google Scholar]
78. Cronin E. Dermatitis of the hands in caterers. Contact Dermatitis. 1987;17(5):265–269. doi: 10.1111/j.1600-0536.1987.tb01475.x. [PubMed] [CrossRef] [Google Scholar]
79. Falleroni A. E., Zeiss C. R., Levitz D. Occupational asthma secondary to inhalation of garlic dust. Journal of Allergy and Clinical Immunology. 1981;68(2):156–160. doi: 10.1016/0091-6749(81)90173-1. [PubMed] [CrossRef] [Google Scholar]
80. Seuri M., Taivanen A., Ruoppi P., Tukiainen H. Three cases of occupational asthma and rhinitis caused by garlic. Clinical and Experimental Allergy. 1993;23(12):1011–1014. doi: 10.1111/j.1365-2222.1993.tb00292.x. [PubMed] [CrossRef] [Google Scholar]
81. Lybarger J. A., Gallagher J. S., Pulver D. W., Litwin A., Brooks S., Bernstein I. L. Occupational asthma induced by inhalation and ingestion of garlic. The Journal of Allergy and Clinical Immunology. 1982;69(5):448–454. doi: 10.1016/0091-6749(82)90120-8. [PubMed] [CrossRef] [Google Scholar]
82. Asero R., Mistrello G., Roncarolo D., Antoniotti P. L., Falagiani P. A case of garlic allergy. Journal of Allergy and Clinical Immunology. 1998;101(3):427–428. doi: 10.1016/s0091-6749(98)70261-1. [PubMed] [CrossRef] [Google Scholar]
83. Pérez-Pimiento A. J., Moneo I., Santaolalla M., De Paz S., Fernández-Parra B., Domínguez-Lázaro A. R. Anaphylactic reaction to young garlic. Allergy. 1999;54(6):626–629. doi: 10.1034/j.1398-9995.1999.00806.x. [PubMed] [CrossRef] [Google Scholar]
84. Clement F., Venkatesh Y. P. Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic. International Immunopharmacology. 2010;10(10):1161–1169. doi: 10.1016/j.intimp.2010.06.022. [PubMed] [CrossRef] [Google Scholar]
85. Yin X., Zhang J., Li X., et al. DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. International Journal of Molecular Sciences. 2014;15(7):12422–12441. doi: 10.3390/ijms150712422. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
86. Senthilkumar G. P., Thomas S., Sivaraman K., Sankar P., Bobby Z. Study the effect of s-methyl L-cysteine on lipid metabolism in an experimental model of diet induced obesity. Journal of Clinical and Diagnostic Research. 2013;7(11):2449–2451. doi: 10.7860/jcdr/2013/7304.3571. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
87. Chandrashekar P. M., Venkatesh Y. P. Identification of the protein components displaying immunomodulatory activity in aged garlic extract. Journal of Ethnopharmacology. 2009;124(3):384–390. doi: 10.1016/j.jep.2009.05.030. [PubMed] [CrossRef] [Google Scholar]
88. Şener G., Sehirli Ö., Ipçi Y., et al. Aqueous garlic extract alleviates isehaemia-reperfusion-induced oxidative hepatic injury in rats. Journal of Pharmacy and Pharmacology. 2005;57(1):145–150. doi: 10.1211/0022357055209. [PubMed] [CrossRef] [Google Scholar]
89. Ernsberger P., Johnson J. L., Rosenthal T., Mirelman D., Koletsky R. J. Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome. American Journal of Hypertension. 2007;20(8):866–874. doi: 10.1016/j.amjhyper.2007.02.015. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
90. Mendis S., Puska P., Norrving B. Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization, World Heart Federation and World Stroke Organization; 2011. [Google Scholar]
91. Kuller L. H., Tracy R. P., Shaten J., Meilahn E. N. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. American Journal of Epidemiology. 1996;144(6):537–547. doi: 10.1093/oxfordjournals.aje.a008963. [PubMed] [CrossRef] [Google Scholar]
92. Ridker P. M., Hennekens C. H., Roitman-Johnson B., Stampfer M. J., Allen J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. The Lancet. 1998;351(9096):88–92. doi: 10.1016/s0140-6736(97)09032-6. [PubMed] [CrossRef] [Google Scholar]
93. Ridker P. M., Hennekens C. H., Buring J. E., Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. The New England Journal of Medicine. 2000;342(12):836–843. doi: 10.1056/nejm200003233421202. [PubMed] [CrossRef] [Google Scholar]
94. Vazquez-Prieto M. A., Rodriguez Lanzi C., Lembo C., Galmarini C. R., Miatello R. M. Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. Journal of Nutrition and Metabolism. 2011;2011:7. doi: 10.1155/2011/475216.475216 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
95. Guzik T. J., Sadowski J., Guzik B., et al. Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26(2):333–339. doi: 10.1161/01.atv.0000196651.64776.51. [PubMed] [CrossRef] [Google Scholar]
96. Miatello R., Vázquez M., Renna N., Cruzado M., Zumino A. P., Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. The American Journal of Hypertension. 2005;18(6):864–870. doi: 10.1016/j.amjhyper.2004.12.012. [PubMed] [CrossRef] [Google Scholar]
97. Liu C., Cao F., Tang Q. Z., et al. Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways. Journal of Nutritional Biochemistry. 2010;21(12):1238–1250. doi: 10.1016/j.jnutbio.2009.11.001. [PubMed] [CrossRef] [Google Scholar]
98. Ide N., Lau B. H. S. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-κB activation. Journal of Nutrition. 2001;131(3):1020S–1026S. [PubMed] [Google Scholar]
99. van Doorn M. B. A., Santo S. M. E., Meijer P., et al. Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects. The American Journal of Clinical Nutrition. 2006;84(6):1324–1329. [PubMed] [Google Scholar]
100. Campbell J. H., Efendy J. L., Smith N. J., Campbell G. R. Molecular basis by which garlic suppresses atherosclerosis. Journal of Nutrition. 2001;131(3) [PubMed] [Google Scholar]
101. Sitia S., Tomasoni L., Atzeni F., et al. From endothelial dysfunction to atherosclerosis. Autoimmunity Reviews. 2010;9(12):830–834. doi: 10.1016/j.autrev.2010.07.016. [PubMed] [CrossRef] [Google Scholar]
102. Morihara N., Ide N., Weiss N. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. Journal of Ethnopharmacology. 2011;134(3):711–716. doi: 10.1016/j.jep.2011.01.021. [PubMed] [CrossRef] [Google Scholar]
103. Ried K., Frank O. R., Stocks N. P. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. European Journal of Clinical Nutrition. 2013;67(1):64–70. doi: 10.1038/ejcn.2012.178. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
104. Steiner M., Khan A. H., Holbert D., Lin R. I.-S. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. The American Journal of Clinical Nutrition. 1996;64(6):866–870. [PubMed] [Google Scholar]
105. Reinhart K. M., Coleman C. I., Teevan C., Vachhani P., White C. M. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. Annals of Pharmacotherapy. 2008;42(12):1766–1771. doi: 10.1345/aph.1l319. [PubMed] [CrossRef] [Google Scholar]
106. Ried K., Frank O. R., Stocks N. P. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010;67(2):144–150. doi: 10.1016/j.maturitas.2010.06.001. [PubMed] [CrossRef] [Google Scholar]
107. Budoff M. J., Ahmadi N., Gul K. M., et al. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Preventive Medicine. 2009;49(2-3):101–107. doi: 10.1016/j.ypmed.2009.06.018. [PubMed] [CrossRef] [Google Scholar]
108. Gonen A., Harats D., Rabinkov A., et al. The antiatherogenic effect of allicin: possible mode of action. Pathobiology. 2006;72(6):325–334. doi: 10.1159/000091330. [PubMed] [CrossRef] [Google Scholar]
109. Jain R. C., Konar D. B. Effect of garlic oil in experimental cholesterol atherosclerosis. Atherosclerosis. 1978;29(2):125–129. doi: 10.1016/0021-9150(78)90002-3. [PubMed] [CrossRef] [Google Scholar]
110. Dirsch V. M., Keiss H.-P., Vollmar A. M. Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells. European Journal of Nutrition. 2004;43(1):55–59. doi: 10.1007/s00394-004-0437-7. [PubMed] [CrossRef] [Google Scholar]
111. Hotamisligil G. S. Inflammation and metabolic disorders. Nature. 2006;444(7121):860–867. doi: 10.1038/nature05485. [PubMed] [CrossRef] [Google Scholar]
112. Gregor M. F., Hotamisligil G. S. Inflammatory mechanisms in obesity. Annual Review of Immunology. 2011;29:415–445. doi: 10.1146/annurev-immunol-031210-101322. [PubMed] [CrossRef] [Google Scholar]
113. Lumeng C. N., Deyoung S. M., Bodzin J. L., Saltiel A. R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56(1):16–23. doi: 10.2337/db06-1076. [PubMed] [CrossRef] [Google Scholar]
114. Liu J., Divoux A., Sun J., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nature Medicine. 2009;15(8):940–945. doi: 10.1038/nm.1994. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
115. Ohmura K., Ishimori N., Ohmura Y., et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30(2):193–199. doi: 10.1161/atvbaha.109.198614. [PubMed] [CrossRef] [Google Scholar]
116. Keophiphath M., Priem F., Jacquemond-Collet I., Clément K., Lacasa D. 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. Journal of Nutrition. 2009;139(11):2055–2060. doi: 10.3945/jn.109.105452. [PubMed] [CrossRef] [Google Scholar]
117. D’Elios M. M., Amedei A., Del Prete G. Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma. Microbes and Infection. 2003;5(8):723–730. doi: 10.1016/s1286-4579(03)00114-x. [PubMed] [CrossRef] [Google Scholar]
118. Khosla P., Karan R. S., Bhargava V. K. Effect of garlic oil on ethanol induced gastric ulcers in rats. Phytotherapy Research. 2004;18(1):87–91. doi: 10.1002/ptr.1349. [PubMed] [CrossRef] [Google Scholar]
119. Oommen S., Anto R. J., Srinivas G., Karunagaran D. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. European Journal of Pharmacology. 2004;485(1–3):97–103. doi: 10.1016/j.ejphar.2003.11.059. [PubMed] [CrossRef] [Google Scholar]
120. Kim J. Y., Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims. The American Journal of Clinical Nutrition. 2009;89(1):257–264. doi: 10.3945/ajcn.2008.26142. [PubMed] [CrossRef] [Google Scholar]
121. Suddek G. M. Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals. Pharmaceutical Biology. 2014;52(8):1009–1014. doi: 10.3109/13880209.2013.876053. [PubMed] [CrossRef] [Google Scholar]
122. Miron T., Mironchik M., Mirelman D., Wilchek M., Rabinkov A. Inhibition of tumor growth by a novel approach: in situ allicin generation using targeted alliinase delivery. Molecular Cancer Therapeutics. 2003;2(12):1295–1301. [PubMed] [Google Scholar]
123. Shin D. Y., Kim G.-Y., Hwang H. J., Kim W.-J., Choi Y. H. Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environmental Toxicology and Pharmacology. 2014;37(1):74–83. doi: 10.1016/j.etap.2013.11.002. [PubMed] [CrossRef] [Google Scholar]
124. Xu L., Yu J., Zhai D., et al. Role of JNK activation and mitochondrial bax translocation in allicin-induced apoptosis in human ovarian cancer SKOV3 cells. Evidence-Based Complementary and Alternative Medicine. 2014;2014:6. doi: 10.1155/2014/378684.378684 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
125. Sigounas G., Hooker J., Anagnostou A., Steiner M. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutrition and Cancer. 1997;27(2):186–191. doi: 10.1080/01635589709514523. [PubMed] [CrossRef] [Google Scholar]
126. Amagase H., Milner J. A. Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis. 1993;14(8):1627–1631. doi: 10.1093/carcin/14.8.1627. [PubMed] [CrossRef] [Google Scholar]
17 likes
Idiotic spam Darcy
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I have reported you, not for your opinion, which anyone can see is ignorant and mis informed which you are welocme to indulge yoursef in, but because you are a moron that the public should be protected from, a career at the bbc seems in order for you
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Darcy – the reports come to me . I notice that you posted the long reference at 0458 Sunday morning . I’m sure it’s of value to someone . If you want to call people ‘morons ‘ on this site please go find one where such rudeness is more’ the norm’ – also don’t post very bad words which I have to spend time editing . ( it was on one of your night time posts ) .
Signed Fedup2 – a moderator
8 likes
You refer to rudeness please refer to the poster who called me “idiotic” when i referred to science and logic,
as to your other complaint I can only assume that your reference to the time of the post makes an assumption that night time posts are of less value than daytime well .. we will let that judgement hang
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Darcy – don’t put the c word in your posts whatever the time of day or however you misspell it .
2 likes
A link would have sufficed, to save the scroll finger.
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Yes it would, but. would it have the same impact as to the bbc lack of references ?
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30 likes
Cummings and Boris better have a word with OfCom . Having watched that video post . Why would AlBeeb want to undermine the President of the USA?
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How the BBC works:
1. Edit down 50 minutes plus of multiple-presenter briefing to just a few minutes of Presidential speculation.
2. Top and tail it with sarcastic voice-over by BBC female.
3. Broadcast it.
4. Wait for response from UK ‘experts’ to BBC News’ made-up-story.
5. Report ‘confirmation’ by UK ‘expert’ that, on the basis of a BBC film designed to make the president look like an idiot, he looked like an idiot.
Or to put it more simply, make up a fake news story, show it to someone with some creditability that trusts you, then report their comments as fact!
That is the equivalent of criminals ‘laundering’ money!
News laundering: The process of feeding a fake news story to a trusted authority so as to get it regenerated as fact.
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It takes Politico 11 mins to explain how the bBC deceives the casual viewer using a very short clip of its own manufacture. It is a good example of what the bBC does scores of times a day and why many people have given it up altogether.
I wonder how long the bBC took to engineer their clip, how much plotting and planning and scheming it took, and how much it cost the TAXpayer? How many bBC operatives in total were involved in the deception?
In a just society run by normal people, measures would be taken immediately against:
the bBC – obviously
OfCom – who should have already acted as ‘watchdog’ and seen what Politico saw
Kings College – who apparently hire sub-standard staff
Clearly all three are not fit for purpose and are not acting according to their designated remit(s).
Of course these three are not the only ‘institutions’ that are not fit for purpose.
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island -Is Ofcom not stuffed full of former bbc employees, or people with bbc connections? One big, happy family, I gather, as the lack of any action against the wilder beeb propaganda, attests.
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Very interesting. However I think he’s being unfair in making out that Trump misunderstood the disinfectant part. It seems to me that Trump was noting the effect of disinfectant on contact and wondering if you could get the same effect by injecting the UV light to make internal contact.
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Yes, RD. The President has a poor way with English language as you demonstrated by putting up some of the actual text used in the briefing. Think POTUS was possibly/probably making an instant leap to endoscopy/bronchoscopy because he’s an ‘ideas man’. He’s heard of organ washing and blood washing being done as part of various treatments, including transplants, and floated out an idea because that’s what he likes to do.
I hope this rebounds on the BBC. If I was a journalist wanting to make a name (and probably live dangerously), I’d be looking at links between the BBC and the Democratic Party in America. The BBC are really out to ‘get Trump’ and ‘sink Trump’. In the opposite way to old man Hearst saying to his publications in the early 1950s ‘puff Graham’. He wanted them to publicise and cover Billy Graham’s growing worldwide ministry – and get some sales on the back of it.
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Beeb reporters can now mind-read, apparently: “The scientist… could barely conceal her thoughts on the President’s idea.”
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Maybe the President’s poor choice of words from time to time will be visited upon his detractors, the BBC being chief.
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Viruses are highly adaptable, and have developed ways to avoid detection by T cells. Some viruses stop MHC molecules from getting to the cell surface to display viral peptides. If this happens, the T cell doesn’t know there’s a virus inside the infected cell.
However, another immune cell specialises in killing cells that have a reduced number of MHC class I molecules on their surface – this cell is a natural killer cell or NK cell for short. When the NK cell finds a cell displaying fewer than normal MHC molecules it releases toxic substances, in a similar way to cytotoxic T cells, which kill the virally-infected cell.
https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/immune-responses-viruses
” In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils,”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417560/
23 likes
Things the bbc syense editor is unlikely to be aware of, or any other of their wurld klass gernaliss, unless, of course, their local mosque instructs 300 muzzies to email them the info
that tends to direct their editorial content, whilst the 85% indigenous population that fund the bbc may as well urinate into a typhoon as expect their voices to be heard, or their interests or concerns represented
RE Easter vs rama bleeding dam
31 likes
Collateral effect.
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GW,
As every day wears on, looking more like a Garden Gnome.
15 likes
Shots fired.
29 likes
Concluded by dropping Little Boy.
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Why is a BBC employee talking to a likely member of SAGE and leaking it to social media?
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Regarding my above rant, the point I should really have made is the bbc used the word “fake”, viruses are effective at killing people with lowered immune systems, who is spreading fake news?
My personal recommendation: Vitamin D3, E and C (1000mg) supplements, selenium, garlic capsules and a B complex
Doctors always say a balanced diet etc etc who can manage that when you have to queue to get into a shop ? and to get the above into your diet you would be eating all day
and regarding the mediterranian diet, well thats done them a lot of good has it not, Italian coffin makers are doing well
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Darcy – interesting. Please comment on consumption frequency re the above.
1 likes
Wrong end of Italy, old chap. 😉
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Donald Trump retweeted a warning about –
“Household cleaners and disinfectants can cause health problems when not used properly..
What I find interesting is the thought that it isn’t the job of the media to take it upon themselves to issue warnings about anything because that is the job of the appropriate body of a properly elected government and in this case the CDC
6 likes
Easy to see why they are deemed ‘essential’.
9 likes
I thought we gave up running when we learnt how to farm a few thousand years ago , especially running when dressed as a chicken / gorilla etc and I am willing to bet none of the hunter gatherers did interviews on the bbc about raising money for their local child minding cave whilst dismembering a mammoth
I could be wrong, I will leave it to the bbc Arkiolgist experts to discuss, I suspect they will find evidence of a neanderthal red nose day somewhere or other with a Lenny Henry ancestor doing funny things with fire
32 likes
If ever there was evidence of too many BBC journalists these trawls for stories is it. To 99% of us whatever someone is doing instead of running will be plain boring. If someone is doing something interesting, they are too busy doing it and not contacting the BBC.
11 likes
R4 Religion prog
BBC gives us BBO
…………………. Bias By Omission
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8:04am The gangster funeral came up in the news
with the charging of the gun man
I bet you can’t guess his first name .
“Greater Manchester Police ALLOWED hundreds of mourners, citing public safety”
20 likes
When media find polls can be bad as well as good.
16 likes
Somewhere a 10yo and 19yo are plotting an outrage…
8 likes
FFS – coping!…well judging from where I live they are all meeting up in my street..
My puzzle is why they are saying some years will have to retake a whole year because of what they are missing… Nowadays they have the bloody internet/online teaching – what exactly is the reason they can’t keep up with school work?
Why are the teachers not delivering lesson using Teams or Zoom like we are…
Oh I forgot they are Key workers – duh! only not working. Sorry Rant over…
3 likes
The second item on the R4 Religion prog
was Muslim advertising agency
Mud Orange – a new ‘creative agency’
launched at the start of this year’s Ramadan
– is, according to its founders,
the first in the Western world to specialise in targeting the Muslim consumer,
while aiming to reshape the public image of Muslims.”
8 likes
I wonder if they will run into trouble over gay issues.
18 likes
I suspect they will be recruiting architects specialising in tall buildings with flat roofs and suppliers of hole diggers and stones
and publishers of an A to Z of local schools and care homes within easy reach of a Vauxhall Vectra taxi with no MOT that refuses to provide a service to blind people because they hate dogs
hate and intolerance being the operative words
28 likes
Stew, I winced a bit at that name.
Kinda racist.
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I look forward to all those hijab-ed mummies with their black husbands and mixed-race kids buying sofas, eating bacon burgers and celebrating Christmas!
Souviens-toi de Charlie.
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In other words more propaganda and brainwashing.
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Beeb in full on “No Male Utopia” mode yesterday on their front page. The only pic of a male (white of course) was an illustration of him sending a “revenge porn” video further up. We’re all not that Beeboids, or have you got an agenda?
12 likes
800 people a day dying with the Chinese virus .
The government doesn’t make the locations and ages of those poor souls available to the public .
Care Homes deaths – which I suspect are ‘ off the books’ and take weeks to go on the statistics are a horror and will be the scandal that comes out of the handling of this
Can anyone see anyone coming out of this well ? ( apart from anyone who invents the miracle vaccine ) ?
17 likes
Unfortunately, care homes are businesses, I knew a lady that worked in one a while ago, the smell of urine as I walked in..it takes a certain kind of person that can cope with dying, very ill people at the end of their life, and have lost control of their bowels, I could not, and as a business, without the resources given to the NHS I cannot see how they can cope
26 likes
There are, particular kinds of people that do that job, I have met a few and they don’t need to be clapped, because if I was one of them I would be saying
“where were you over the last 20 years when I have been looking after people who are dying ?”
There is bugger all going on in A and E and we have time to dance IN PPE wheres the valium cabinet…thats always short for some strange reason
31 likes
Rumour has it that Bill Gates is already on the job, we are currently going through the Control, Alter, Delete process
But will the PC world succesfully ‘re-boot’?
3 likes
Triggered “People are really mad over Islam question that Jeff Goldblum asked on Drag Race”
https://www.breitbart.com/entertainment/2020/04/25/jeff-goldblum-faces-backlash-for-questioning-the-anti-homosexuality-and-anti-woman-nature-of-islam
18 likes
@afneill is a shill, he should STF up
‘Views my own’ no defence for opinions shared on Twitter by BBC News staff, updated guidelines state
Previous guidelines said only that a similar disclaimer that retweets do not signify endorsement “may not be enough”.
BBC editorial staff and anyone who identifies “as being linked with the BBC”, have now been formally told that sharing their opinions online or in the press could “compromise the BBC’s impartiality” and “damage its reputation”.
The risk is greater where the public expressions of opinion overlap with the area of the individual’s work,” the guidelines state”
https://www.pressgazette.co.uk/bbc-news-staff-social-media-rules-editorial-guidelines-update-twitter-views-my-own/
7 likes
Fight!
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@CM Beeboids tweets “COULD compromise the BBC’s impartiality and damage its reputation.
Horse / stable / door
What “impartiality” ?
What “reputation” ?
4 likes
When everyone is suffering
The “China” virus could save the BBC?
“BBC, NY Times and Guardian among biggest winners as Covid-19 sends global news traffic soaring”
https://www.pressgazette.co.uk/bbc-ny-times-and-guardian-among-biggest-winners-as-covid-19-sends-global-news-traffic-soaring/
11 likes
OK we get it the purple haired pierced left anti government agenda is
dont follow science follow our opinion
Yep, sod Copernicus, sod Newton, sod Einstein only the labour party matter and a virus can be racist….
and the amazing thing is some of them got into a university.. and probably part of the Minnesota Flat Earth study group in big Earls back shed
with lara carlsgberg handing out vol au vents
24 likes
Can you guarantee, Minister that our fleet will not fall off the edge of the earth if it sails too far? and to follow, why have you not paid the families of those lost sailors ?
19 likes
On Marr this morning (Yes, I subjected myself to some self harm!!)…The next German Ambassador to the UK was asked ‘Why is the German response so much more effective than the UK’s approach’.
His reply was basically One word, TESTING! Aggressive, Test, Trace, Isolate. Then Repeat!
Matt Hancock to Parliament 27th Janaury 2020 stated: “The UK is one of the first countries in the world to have developed an accurate test for this coronavirus and PHE is undertaking continuous refinement of this test. PHE has this morning confirmed to me that it can scale up this test so we are in a position to deal with cases in this country if necessary.”
…..comments?
12 likes
The BBC’s admiration for Germany stems from two things: (1) it is not Britain and (2) it’s the heart of their beloved EU. We do not yet know the reasons why their response currently *appears* to be more effective. But, one factor might be in the way that deaths are attributed. The Germans are very precise in these matters (‘shot to death’, ‘died in concentration camp’, ‘died during death march’ etc), whereas the British response seems to be along the lines of ‘Had a bit of a cold a few months back? Put the cause down as Covid-19’. Ditto in the US, where there is no longer any burden of proof and it is merely sufficient to say ‘probably’ down to Covid-19 without any testing at all.
24 likes
I concur with the sycophantic relationship between the BBC, Germany and the EU.
I also agree the German counting is precise. Our teutonic cousins have form here. However, I do not agree with your Perception of the British counting system.
Reports suggest the opposite of what you claim. Doctors are reluctant to add Covid to the Death Cert. And the Care home figures are a complete unknown.
In contrast to that 2 points. I’m not defending the BBC here.
1. Our counting is clearly not precise, potentially bias to under-representation. It’s, therefore, likely to be far higher than the ‘hospital only figures’ presented to us.
2. Matt Hancock lied to Parliament and the nation on January 27th.
Why are the BBC and the media not ‘on this’? Why are the BBC and the Media not ‘on the migrant crossing crisis’? Why are the media not on the ’15K’ people enter our country unchecked every day?
Macron stated yesterday ‘France’s borders remain closed’. Why are ours open.
12 likes
Jugears Marr let the ghastly droning Rachel Reeves drone on without interruption. Nicola Krankie-Sturgeon didn’t give Jugears any information on when he might be allowed to visit his aged parents outside Dundee. Jugears didn’t insist that Krankie give him the precise date and time that he might be so allowed…as he would if it were a Tory minister.
Wonder why?
27 likes
Three weeks to show ? so testing does what ?
11 likes
Darcy / Venut,
Am I missing something? You can test all you want but without a cure……… A statisticians wet dream.
Only reason you might extend vetting is if you were 100% sure that a previously infected person could not re-acquire and spread the chinese virus. That’s one of the big unknowns. But, the statisticians have to have their say so for them more more and even more testing is good for their business. Maybe if we follow this rolling snowball downhill and find a staggering number of the population are infected through testing, we might conclude that, that, that, lockdown and isolation is the only safe way……………..
10 likes
G/Darcy
Testing, tracing and isolating. The German,S Korean, Australian etc etc method is clearly successful.
1. Testing shines light. It allows policy to intelligently adapt to what’s happening in the on the ground. At present we have absolutely no idea what the hell is happening or where. Who has it? And precisely where they have it. All we know is patients ‘rock up’ to A+E. generally more in some areas than others. This is not good enough.
Testing sheds light on this and allows policy to, ‘totally lock down’ in say “London’ while keeping a ‘soft Lockdown’ in say Cornwall.
It’s just smart.
2. Community test en masse stops spread. Given many who carry this virus are asymptomatic. You can identify through testing, immediate isolate, trace contacts. Isolate them (and I really mean isolate – not texting your whereabouts every few days) re-test and prevent further spread. This is exactly what S Korea/Austarlia do/did so successfully.
3. While testing is not a cure. If you continually test, then restrictions can be lifted and applied as necessary rather than an entire nation sat in ‘like lemons’ clapping like morons or moaning.
At the minute we do not test. It makes policy blunt, weak and fuzzy.
We all suffer because of our lack of testing. While I hate the BBC, our government is second rate. The response is a joke.
We need ‘war’ leaders, not middle management career politicians. I also include the opposition (and the rest of the joke MPs in parliament) in this group too (for clarification).
7 likes
Open everything up again. Holiday in this country. Children go back to school, but as they can be the biggest ‘carriers’, make wearing masks and gloves mandatory, treat everyone as though they have the plague and keep the social distancing for 12 months. Hugging and physical contact may be missed, but isn’t it a price worth paying in exchange for not being laid out with a respirator with only a 50/50 chance of surviving ? I certainly can.
10 likes
Don’t forget all, essential viewing today on al beeb 1 – The 1981 London Marathon: A Historical First! ????
And people pay for this sh*t? ????
I wonder if Jimmy Savile’s fundraising will feature ????
16 likes
There are lots of pertinent comments and questions attached to the article.
Yesterday I saw a comment from a Royal Marine on twitter saying (I paraphrase) give him a few weeks and the resources and he would have the problem solved. So I say – put the Marines in charge of Border Farce. It’s obvious.
I used to dismiss ‘conspiracy’ theories but it is difficult to ignore the one about deliberate population replacement.
27 likes
Found it
20 likes
On the military, I remember a thought provoking if skewed movie which had Bruce Willis as a general tasked by panicking pols to address a collapse in civil order due to terrorism. Before taking it on he advises that they won’t like what it takes. They don’t. And I think he gets shafted.
The era of rough men being able to do the jobs others won’t was crushed years ago in every edit suite in the hands of the wrong journalist. Which means every journalist.
3 likes
I can’t remember where I read it, maybe on here or the DT but several comments have appeared saying that the number of deaths we get in the daily stats are up to 3 weeks old as it takes that time to get all the paperwork and stuff done.
Basically, today’s numbers are those who died on 5 April or thereabouts.
The comments all say that the number of deaths occurring today, yesterday and recently are in the 100’s, still a lot but far better than the 700’s we are being told.
They say (commentators) they have found out these numbers by monitoring nhs sites (or something like that)
I have no idea if these numbers are true but if so it should mean in about 3 weeks we should be having daily rates of 100 or so.
You would think that someone in the media would point this out if there is any substance to it, it’s certainly worth looking at.
My default position is that I cannot believe anything the msm or government say as everything now has an agenda or bias.
I wish the bbc was an impartial news provider but it’s now just the same as the rest, an agenda driven lefty organisation.
Has anyone got any suggestions of an impartial news source?
15 likes
I think Fedup2 suggested Reuters at one point.
https://uk.reuters.com
4 likes
Half price for kids and reduced entrance in your local mosque
and I quote “you white F@cking bitch ” as 12 pakis raped and whipped her a 12 year old girl
12 year old girl and NOT treated as a racially agravated crime
24 likes
It is fascinating the Labour party has desperatly tried to create race hatred, the only reason the stabbed Stephen Lawrence came to prominence was because his father worked for a Daily Mail reporter, the absolute plethora of blacks stabbiing around london is ignored
29 likes
AND another thing, how many wimmin have you seen wandering about in NHS”uniforms” so many around now for some strange reason, hmm they seem to wear them all day long
we have to worship
I have to drive 40 miles three days a week to sort other things out
luckily have never got the clap I understand it is painful
‘I dont dress myself in a blue smock and walk around expecting applause
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I have always thought it was a very unclean habit to come out of place of work whether it be a hospital or a nursing home wearing a uniform that’s been used all day attending to sick patients. I still cannot understand how hospitals allow this. I have had same opinion even before this outbreak. I’ve always maintained they should go in their own clothes, change when they are there and bring back dirty uniform in carrier bag for washing. These same staff just wander into supermarkets or sit next to people on public transport. I dont know why this hasnt been picked up by hospital admin.
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cromwell
Agree entirely. We do not have a car and rely on buses, which are often crowded, and regularly see health workers/nurses travelling in uniform.
I suppose if they are required to travel in their own clothes there will be a call from certain quarters for a substantial ‘clothing allowance’.
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Back when there were ‘proper’ matrons and nurses homes, they wouldn’t be allowed in public in uniform, AND they had to look pristine clean on duty – sadly lacking now. Equally you often see operating operatives with flapping gowns, head gear and masks roaming free in the hospital – whats that all about ? White coats have gone, so anyone with a stethoscope around their neck could be examining you. Our ‘progressive’ NHS for you.
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Hattie Jacques is the role model here. Yes, they were only films, but she still set the gold standard for how nurses should look.
Oooh, matron!
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Brissles, we used to see nurses out and about in London …
… but ….
they would be wearing caps and capes or cloaks in winter and were always immaculate.
Seem to recall from my time
‘in the slammer’sorry, hospital as a kid, that Matron or a Ward Sister would inspect the nurses coming on duty, much as a British Police Station Sergeant would hold a line up of Constables before they went on duty.3 likes
In other essential news, the BBC report that ‘India’s circuses struggle to survive the lockdown’.
What a bunch of clowns.
https://www.bbc.co.uk/news/world-asia-india-52407534
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Richard Dawkins is great
but has tweeted stuff like this
7 March : Denying evolution & climate change,
denying that smoking kills
& condoms protect against AIDS,
denying science again & again,
Pence’s track record in the world of facts
would naturally make him Trump’s top choice
to lead the fight against an epidemic
links to Newsweek article
https://t.co/KSKTUjJ9g4
Then former beeboid Gavin Esler retweets
& adds sneers at the Climate Realists cos they are so inferior to him.
Is it at all possible @richarddawkins
that the coronavirus outbreak might persuade
anti-vaxxers, climate change deniers and other flat-Earthers
that science, knowledge, facts,
Enlightenment values and experts are actually useful?
Esler is misrepresenting Climate Change Realists, and doing false analogy to smear them.
cos of course such Realists do respect “enlightenment values”, proper science, proper scientific method
fact-not-speculation
& not having certainty beyond the available evidence etc.
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With the world going to hell in a handbasket, how reassuring that the beeb still find the time and space and (your) money to report on a tranny in a long, long, long piece of agitprop – sorry, ‘article’. Complete with undertones of antisemitism.
“Ultra-Orthodox and trans: ‘I prayed to God to make me a girl'”
https://www.bbc.co.uk/news/stories-51928077
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